Depression and anxiety, peripheral blood inflammatory factors, and stress levels on therapeutic outcomes in patients with chronic wounds

Table 1 General data of patients with chronic wounds, n (%)

Index	Effective group (n = 95)	Ineffective group (n = 15)	χ2/t	P value
Age (year), mean ± SD	56.09 ± 13.89	54.20 ± 18.11	0.470	0.639
Sex	/	/	0.322	0.571
Man	56 (58.95)	10 (66.67)	/	/
Woman	39 (41.05)	5 (33.33)	/	/
Educational level	/	/	0.006	0.938
Junior college or below	58 (61.05)	9 (60.00)	/	/
College degree or above	37 (38.95)	6 (40.00)	/	/
Wound area (cm2), mean ± SD	5.29 ± 1.54	7.73 ± 1.79	5.586	< 0.001
Wound type	/	/	0.454	0.978
Pressure ulcer	21 (22.11)	4 (26.67)	/	/
Venous blood ulcer	18 (18.95)	3 (20.00)	/	/
Diabetic foot ulcers	16 (16.84)	3 (20.00)	/	/
Traumatic ulcer	23 (24.21)	3 (20.00)	/	/
Other	17 (17.89)	2 (13.33)	/	/
Wound infection	/	/	11.579	< 0.001
Yes	32 (33.68)	12 (80.00)	/	/
No	63 (66.32)	3 (20.00)	/	/
Participates in physical exercise	/	/	0.750	0.387
Yes	71 (74.74)	5 (33.33)	/	/
No	24 (25.26)	10 (66.67)	/	/
Daily bed time (hour), mean ± SD	11.71 ± 2.36	15.93 ± 2.40	6.431	< 0.001

Table 2 Logistic regression model assignment situation

Variables	Assignments
Clinical efficacy	1: Ineffective, 0: Effective
Wound area	1: ≥ 7 cm2, 0: < 7 cm2
Wound infection	1: Yes, 0: No
Daily bed time	1: ≥ 14 hours, 0: < 14 hours
HAMA	1: ≥ 9 scores, 0: < 9 scores
HAMD	1: ≥ 8 scores, 0: < 8 scores
IL-6	1: ≥ 19 pg/mL, 0: < 19 pg/mL
TNF-α	1: ≥ 63.88 pg/mL, 0: < 63.88 pg/mL
MDA	1: ≥ 41 nmol/L, 0: < 41 nmol/L

HAMD: Hamilton Depression Rating Scale; HAMA: Hamilton Anxiety Rating Scale; IL-6: Interleukin-6; TNF-α: Tumor necrosis factor-alpha; MDA: Malondialdehyde.

Table 3 Multivariate logistic analysis of factors influencing clinical efficacy in patients with chronic wounds

Variable	B	SE	Wald χ2	P value	OR	95%CI
Wound area	2.796	1.408	3.943	0.047	16.374	1.037-258.609
Wound infection	0.062	1.343	0.002	0.963	1.064	0.077-14.787
Daily bed time	2.170	1.695	1.640	0.200	8.761	0.316-242.699
HAMA	4.613	1.869	6.094	0.014	100.790	2.587-3927.125
HAMD	4.510	1.892	5.684	0.017	90.937	2.231-3707.301
IL-6	0.917	1.323	0.480	0.488	2.501	0.187-33.450
TNF-α	0.164	1.323	0.015	0.902	1.178	0.088-15.752
MDA	2.934	1.716	2.923	0.087	18.797	0.651-542.754

OR: Odds ratio; CI: Confidence interval; HAMD: Hamilton Depression Rating Scale; HAMA: Hamilton Anxiety Rating Scale; IL-6: Interleukin-6; TNF-α: Tumor necrosis factor-alpha; MDA: Malondialdehyde.

Table 4 Receiver operating characteristic curve analysis of the related variables

Variable	AUC	SE	95%CI	P value
Wound area	0.767	0.063	0.676-0.842	< 0.001
HAMA	0.805	0.057	0.719-0.875	< 0.001
HAMD	0.768	0.058	0.678-0.844	< 0.001
United	0.940	0.0297	0.878-0.976	< 0.001

CI: Confidence interval; HAMD: Hamilton Depression Rating Scale; HAMA: Hamilton Anxiety Rating Scale; AUC: Area under the curve.