Li B, Li C, Zhong XJ, Xu XR. Depression and anxiety, peripheral blood inflammatory factors, and stress levels on therapeutic outcomes in patients with chronic wounds. World J Psychiatry 2024; 14(12): 1836-1844 [PMID: 39704378 DOI: 10.5498/wjp.v14.i12.1836]
Corresponding Author of This Article
Xiang-Rong Xu, Chief Physician, Department of Burns and Plastic Surgery, Changde Hospital, Xiangya School of Medicine, Central South University (The First People’s Hospital of Changde City), No. 818 Renmin Road, Wuling District, Changde 415000, Hunan Province, China. 13973661455@163.com
Research Domain of This Article
Psychiatry
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Psychiatry. Dec 19, 2024; 14(12): 1836-1844 Published online Dec 19, 2024. doi: 10.5498/wjp.v14.i12.1836
Depression and anxiety, peripheral blood inflammatory factors, and stress levels on therapeutic outcomes in patients with chronic wounds
Bo Li, Cha Li, Xian-Jiang Zhong, Xiang-Rong Xu
Bo Li, Xiang-Rong Xu, Department of Burns and Plastic Surgery, Changde Hospital, Xiangya School of Medicine, Central South University (The First People’s Hospital of Changde City), Changde 415000, Hunan Province, China
Cha Li, Department of Pediatric Intensive Care Unit, Changde Hospital, Xiangya School of Medicine, Central South University (The First People’s Hospital of Changde City), Changde 415000, Hunan Province, China
Xian-Jiang Zhong, Department of Psychiatry, The First People’s Hospital of Xiantao, Xiantao 433099, Hubei Province, China
Author contributions: Li B and Xu XR designed the study; Li B and Li C performed data extraction and wrote the manuscript; Zhong XJ provided professional support; and all authors read and approved the final version.
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board of Changde Hospital, Xiangya School of Medicine, Central South University (The First People’s Hospital of Changde City), approval No. 2024-148-01.
Informed consent statement: The informed consent was waived by the Institutional Review Board.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The anonymous data used in this study can be obtained from the corresponding author upon request.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiang-Rong Xu, Chief Physician, Department of Burns and Plastic Surgery, Changde Hospital, Xiangya School of Medicine, Central South University (The First People’s Hospital of Changde City), No. 818 Renmin Road, Wuling District, Changde 415000, Hunan Province, China. 13973661455@163.com
Received: September 25, 2024 Revised: October 29, 2024 Accepted: November 8, 2024 Published online: December 19, 2024 Processing time: 63 Days and 3.5 Hours
Abstract
BACKGROUND
The incidence of chronic wounds is rising due to an aging population and lifestyle changes in our country. In addition, as the disease spectrum evolves, chronic wounds have become common clinical issues that seriously threaten health and impose significant social and economic burdens.
AIM
To investigate how depression, anxiety, peripheral blood inflammatory factors, and stress levels affect therapeutic outcomes in patients with chronic wounds.
METHODS
Retrospectively collected clinical data from 110 patients with chronic wounds treated at Changde Hospital, Xiangya School of Medicine, Central South University (The First People’s Hospital of Changde City) between January 2021 and December 2023, categorizing them into effective and ineffective groups based on treatment effects. Differences between both groups were analyzed using univariate analysis, independent risk factors identified via logistic regression, and their predictive value assessed through receiver operating characteristic analysis.
RESULTS
Following treatment, 95 cases were classified as the effective group (cured or improved), while 15 cases with improvement formed the ineffective group. Significant differences between both groups were noted in wound area, infection status, daily bed time, Hamilton Anxiety Rating Scale (HAMA) scores, Hamilton Depression Rating Scale (HAMD) scores, and levels of interleukin-6, tumor necrosis factor-alpha, and superoxide dismutase (P < 0.05). Logistic regression analysis identified a wound area ≥ 7 cm2, HAMA ≥ 9 scores, and HAMD ≥ 8 scores were independent risk factors for ineffective treatment in patients with chronic wounds (P < 0.05). The receiver operating characteristic curve analysis revealed that the area under the curve for ineffective treatment based on wound area, HAMA, and HAMD was 0.767, 0.805, and 0.768 respectively.
CONCLUSION
Wound size, anxiety, and depression are significant factors influencing the therapeutic outcomes in patients with chronic wounds that require careful attention, alongside the development of appropriate strategies.
Core Tip: This study retrospectively analyzed clinical data from 110 patients with chronic wounds to assess the effects of depressive and anxious moods, peripheral blood inflammatory markers, and stress levels on treatment outcomes. The results showed an overall efficacy rate of 86.36%, with independent risk factors identified as wound size and depression/anxiety levels. Additionally, peripheral blood inflammatory markers and stress levels were lower in the effective group than in the ineffective group. Therefore, for patients with chronic wound, it is crucial to address not only the wounds but also their psychological well-being and inflammatory stress status to improve treatment effectiveness.
