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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatr. Sep 22, 2015; 5(3): 260-272
Published online Sep 22, 2015. doi: 10.5498/wjp.v5.i3.260
Published online Sep 22, 2015. doi: 10.5498/wjp.v5.i3.260
Role of presynaptic phosphoprotein synapsin II in schizophrenia
Luke Molinaro, Patricia Hui, Mattea Tan, Ram K Mishra, Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
Author contributions: All authors contributed to this manuscript.
Supported by The Canadian Institute of Health Research (CIHR).
Conflict-of-interest statement: All authors declare no conflict of interest regarding the content discussed in this review.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Ram K Mishra, Department of Psychiatry and Behavioural Neurosciences, McMaster University, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada. mishrar@mcmaster.ca
Telephone: +1-905-5259140-22396 Fax: +1-905-5228804
Received: February 5, 2015
Peer-review started: February 7, 2015
First decision: April 10, 2015
Revised: May 26, 2015
Accepted: June 9, 2015
Article in press: June 11, 2015
Published online: September 22, 2015
Processing time: 234 Days and 11 Hours
Peer-review started: February 7, 2015
First decision: April 10, 2015
Revised: May 26, 2015
Accepted: June 9, 2015
Article in press: June 11, 2015
Published online: September 22, 2015
Processing time: 234 Days and 11 Hours
Core Tip
Core tip: The pre-synaptic phosphoprotein, synapsin II, is important in a variety of synaptic functions, including synaptogenesis and regulation of neurotransmitter release. Reduced levels of synapsin II in the prefrontal cortex of humans and animals have been found to confer susceptibility to schizophrenia (SZ). Disruptions in synapsin II gene expression, during development and/or adulthood, may cause synaptic dysfunction, resulting in neurotransmitter imbalances that likely contribute to the pathogenesis of SZ. Understanding synapsin II and its role in disease development will help unravel the pathogenic mechanisms of SZ, and may form the basis for use of novel therapeutics in the treatment of SZ.