Retrospective Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Nov 19, 2024; 14(11): 1661-1670
Published online Nov 19, 2024. doi: 10.5498/wjp.v14.i11.1661
Association between intercellular adhesion molecule-1 to depression and blood-brain barrier penetration in cerebellar vascular disease
Ju-Luo Chen, Rui Wang, Pei-Qi Ma, You-Meng Wang, Qi-Qiang Tang
Ju-Luo Chen, Qi-Qiang Tang, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong Province, China
Ju-Luo Chen, Rui Wang, Qi-Qiang Tang, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, Anhui Province, China
Ju-Luo Chen, Pei-Qi Ma, You-Meng Wang, Department of Neurology, Fuyang People’s Hospital, Fuyang 236000, Anhui Province, China
Author contributions: Chen JL, Wang R and Tang QQ carried out the studies, participated in collecting data, and drafted the manuscript; Ma PQ and Wang YM performed the statistical analysis and participated in its design; Chen JL and Tang QQ participated in the acquisition, analysis, or interpretation of data and drafted the manuscript; all authors read and approved the final manuscript.
Supported by National Natural Science Foundation of China, No. 81573807.
Institutional review board statement: The study was approved by the Ethics Committee of Fuyang People’s Hospital ([2022]26).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All authors declare that they have no conflicts of interest.
Data sharing statement: All data generated or analyzed during this study are included in this published article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Qi-Qiang Tang, Doctor, Professor, Cheeloo College of Medicine, Shandong University, No. 44 Wenhua West Road, Jinan 250012, Shandong Province, China. tqq1995@126.com
Received: August 8, 2024
Revised: September 10, 2024
Accepted: September 18, 2024
Published online: November 19, 2024
Processing time: 91 Days and 0.2 Hours
Core Tip

Core Tip: Cerebral small vessel disease (CSVD) is a prevalent cerebrovascular disease in clinical practice that is often associated with macrovascular disease. A clear understanding of the underlying causes of CSVD remains elusive. Several studies have reported the relationship between intercellular adhesion molecule-1 (ICAM-1) and blood-brain barrier (BBB) penetration in neurological disorders. Thus, this study examined the association between ICAM-1 and BBB penetration in CSVD.