Chen JL, Wang R, Ma PQ, Wang YM, Tang QQ. Association between intercellular adhesion molecule-1 to depression and blood-brain barrier penetration in cerebellar vascular disease. World J Psychiatry 2024; 14(11): 1661-1670 [PMID: 39564172 DOI: 10.5498/wjp.v14.i11.1661]
Corresponding Author of This Article
Qi-Qiang Tang, Doctor, Professor, Cheeloo College of Medicine, Shandong University, No. 44 Wenhua West Road, Jinan 250012, Shandong Province, China. tqq1995@126.com
Research Domain of This Article
Psychiatry
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Ju-Luo Chen, Qi-Qiang Tang, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong Province, China
Ju-Luo Chen, Rui Wang, Qi-Qiang Tang, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, Anhui Province, China
Ju-Luo Chen, Pei-Qi Ma, You-Meng Wang, Department of Neurology, Fuyang People’s Hospital, Fuyang 236000, Anhui Province, China
Author contributions: Chen JL, Wang R and Tang QQ carried out the studies, participated in collecting data, and drafted the manuscript; Ma PQ and Wang YM performed the statistical analysis and participated in its design; Chen JL and Tang QQ participated in the acquisition, analysis, or interpretation of data and drafted the manuscript; all authors read and approved the final manuscript.
Supported byNational Natural Science Foundation of China, No. 81573807.
Institutional review board statement: The study was approved by the Ethics Committee of Fuyang People’s Hospital ([2022]26).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All authors declare that they have no conflicts of interest.
Data sharing statement: All data generated or analyzed during this study are included in this published article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Qi-Qiang Tang, Doctor, Professor, Cheeloo College of Medicine, Shandong University, No. 44 Wenhua West Road, Jinan 250012, Shandong Province, China. tqq1995@126.com
Received: August 8, 2024 Revised: September 10, 2024 Accepted: September 18, 2024 Published online: November 19, 2024 Processing time: 91 Days and 0.2 Hours
Abstract
BACKGROUND
Cerebral small vessel disease (CSVD) is a prevalent cerebrovascular disease in clinical practice that is often associated with macrovascular disease. A clear understanding of the underlying causes of CSVD remains elusive.
AIM
To explore the association between intercellular adhesion molecule-1 (ICAM-1) and blood-brain barrier (BBB) penetration in CSVD.
METHODS
This study included patients admitted to Fuyang People’s Hospital and Fuyang Community (Anhui, China) between December 2021 and March 2022. The study population comprised 142 patients, including 80 in the CSVD group and 62 in the control group. Depression was present in 53 out of 80 patients with CSVD. Multisequence magnetic resonance imaging (MRI) and dynamic contrast-enhanced MRI were applied in patients to determine the brain volume, cortical thickness, and cortical area of each brain region. Moreover, neuropsychological tests including the Hamilton depression scale, mini-mental state examination, and Montreal cognitive assessment basic scores were performed.
RESULTS
The multivariable analysis showed that age [P = 0.011; odds ratio (OR) = 0.930, 95% confidence interval (CI): 0.880-0.983] and ICAM-1 levels (P = 0.023; OR = 1.007, 95%CI: 1.001-1.013) were associated with CSVD. Two regions of interest (ROIs; ROI3 and ROI4) in the white matter showed significant (both P < 0.001; 95%CI: 0.419-0.837 and 0.366-0.878) differences between the two groups, whereas only ROI1 in the gray matter showed significant difference (P = 0.046; 95%CI: 0.007-0.680) between the two groups. ICAM-1 was significantly correlated (all P < 0.05) with cortical thickness in multiple brain regions in the CSVD group.
CONCLUSION
This study revealed that ICAM-1 levels were independently associated with CSVD. ICAM-1 may be associated with cortical thickness in the brain, predominantly in the white matter, and a significant increase in BBB permeability, proposing the involvement of ICAM-1 in BBB destruction.
Core Tip: Cerebral small vessel disease (CSVD) is a prevalent cerebrovascular disease in clinical practice that is often associated with macrovascular disease. A clear understanding of the underlying causes of CSVD remains elusive. Several studies have reported the relationship between intercellular adhesion molecule-1 (ICAM-1) and blood-brain barrier (BBB) penetration in neurological disorders. Thus, this study examined the association between ICAM-1 and BBB penetration in CSVD.
