Retrospective Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Nov 19, 2024; 14(11): 1661-1670
Published online Nov 19, 2024. doi: 10.5498/wjp.v14.i11.1661
Association between intercellular adhesion molecule-1 to depression and blood-brain barrier penetration in cerebellar vascular disease
Ju-Luo Chen, Rui Wang, Pei-Qi Ma, You-Meng Wang, Qi-Qiang Tang
Ju-Luo Chen, Qi-Qiang Tang, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong Province, China
Ju-Luo Chen, Rui Wang, Qi-Qiang Tang, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, Anhui Province, China
Ju-Luo Chen, Pei-Qi Ma, You-Meng Wang, Department of Neurology, Fuyang People’s Hospital, Fuyang 236000, Anhui Province, China
Author contributions: Chen JL, Wang R and Tang QQ carried out the studies, participated in collecting data, and drafted the manuscript; Ma PQ and Wang YM performed the statistical analysis and participated in its design; Chen JL and Tang QQ participated in the acquisition, analysis, or interpretation of data and drafted the manuscript; all authors read and approved the final manuscript.
Supported by National Natural Science Foundation of China, No. 81573807.
Institutional review board statement: The study was approved by the Ethics Committee of Fuyang People’s Hospital ([2022]26).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All authors declare that they have no conflicts of interest.
Data sharing statement: All data generated or analyzed during this study are included in this published article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Qi-Qiang Tang, Doctor, Professor, Cheeloo College of Medicine, Shandong University, No. 44 Wenhua West Road, Jinan 250012, Shandong Province, China. tqq1995@126.com
Received: August 8, 2024
Revised: September 10, 2024
Accepted: September 18, 2024
Published online: November 19, 2024
Processing time: 91 Days and 0.2 Hours
Abstract
BACKGROUND

Cerebral small vessel disease (CSVD) is a prevalent cerebrovascular disease in clinical practice that is often associated with macrovascular disease. A clear understanding of the underlying causes of CSVD remains elusive.

AIM

To explore the association between intercellular adhesion molecule-1 (ICAM-1) and blood-brain barrier (BBB) penetration in CSVD.

METHODS

This study included patients admitted to Fuyang People’s Hospital and Fuyang Community (Anhui, China) between December 2021 and March 2022. The study population comprised 142 patients, including 80 in the CSVD group and 62 in the control group. Depression was present in 53 out of 80 patients with CSVD. Multisequence magnetic resonance imaging (MRI) and dynamic contrast-enhanced MRI were applied in patients to determine the brain volume, cortical thickness, and cortical area of each brain region. Moreover, neuropsychological tests including the Hamilton depression scale, mini-mental state examination, and Montreal cognitive assessment basic scores were performed.

RESULTS

The multivariable analysis showed that age [P = 0.011; odds ratio (OR) = 0.930, 95% confidence interval (CI): 0.880-0.983] and ICAM-1 levels (P = 0.023; OR = 1.007, 95%CI: 1.001-1.013) were associated with CSVD. Two regions of interest (ROIs; ROI3 and ROI4) in the white matter showed significant (both P < 0.001; 95%CI: 0.419-0.837 and 0.366-0.878) differences between the two groups, whereas only ROI1 in the gray matter showed significant difference (P = 0.046; 95%CI: 0.007-0.680) between the two groups. ICAM-1 was significantly correlated (all P < 0.05) with cortical thickness in multiple brain regions in the CSVD group.

CONCLUSION

This study revealed that ICAM-1 levels were independently associated with CSVD. ICAM-1 may be associated with cortical thickness in the brain, predominantly in the white matter, and a significant increase in BBB permeability, proposing the involvement of ICAM-1 in BBB destruction.

Keywords: Cerebral small vessel disease; Intercellular adhesion molecule-1; Blood-brain barrier penetration; Cortical thickness; White matter

Core Tip: Cerebral small vessel disease (CSVD) is a prevalent cerebrovascular disease in clinical practice that is often associated with macrovascular disease. A clear understanding of the underlying causes of CSVD remains elusive. Several studies have reported the relationship between intercellular adhesion molecule-1 (ICAM-1) and blood-brain barrier (BBB) penetration in neurological disorders. Thus, this study examined the association between ICAM-1 and BBB penetration in CSVD.