Retrospective Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Sep 19, 2023; 13(9): 665-674
Published online Sep 19, 2023. doi: 10.5498/wjp.v13.i9.665
Immune function, gastrointestinal hormone levels, and their clinical significance in patients with gastric ulcers complicated with depression
Yun-Han Yang, De-Jun Cui, Zai-Li Yang, Wen-Qiang Yuan, Bo Huang
Yun-Han Yang, De-Jun Cui, Zai-Li Yang, Wen-Qiang Yuan, Bo Huang, Department of Gastroenterology, Guizhou Inflammatory Bowel Disease Research Center, National Institution of Drug Clinical Trial, Guizhou Provincial People’s Hospital, Medical College of Guizhou University, Guiyang 550002, Guizhou Province, China
Author contributions: Yang YH and Cui DJ co-designed the study, wrote the paper, contributed equally to this work, and are the first co-authors; Yang ZL, Yuan WQ, and Huang B participated in the study and provided clinical recommendations.
Supported by the Cultivation Fund of National Natural Science Foundation, No. qiankehe2018-5764-11.
Institutional review board statement: The study was reviewed and approved by Guizhou Provincial People’s Hospital (2023-041).
Informed consent statement: Written informed consent was waived.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: According to institutional policies, third-party access to data is not supported.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yun-Han Yang, MM, Attending Doctor, Department of Gastroenterology, Guizhou Inflammatory Bowel Disease Research Center, National Institution of Drug Clinical Trial, Guizhou Provincial People’s Hospital, Medical College of Guizhou University, No. 83 East Zhongshan Road, Guiyang 550002, Guizhou Province, China. yunhan_y@163.com
Received: July 18, 2023
Peer-review started: July 18, 2023
First decision: August 4, 2023
Revised: August 16, 2023
Accepted: August 25, 2023
Article in press: August 25, 2023
Published online: September 19, 2023
Processing time: 59 Days and 1.7 Hours
Core Tip

Core Tip: The occurrence and severity of gastric ulcer (GU) combined with depression may be related to autoimmune dysfunction and gastrointestinal hormone levels. In this study, multivariate logistic regression analysis was used to influence the severity of concurrent depression in GU. The results suggest that impaired T cell function and gastrointestinal hormone disorders may directly affect the development and development of depression. In addition, the immune function indicators combined with gastrointestinal hormone levels predict high AUC, specificity and sensitivity, which has a very good reference value.