Published online Sep 19, 2023. doi: 10.5498/wjp.v13.i9.665
Peer-review started: July 18, 2023
First decision: August 4, 2023
Revised: August 16, 2023
Accepted: August 25, 2023
Article in press: August 25, 2023
Published online: September 19, 2023
Psychophysiological factors play a significant role in the pathogenesis of gastrointestinal illnesses. Gastric ulcers (GU) are characterized by repeated attacks that can cause adverse severe psychological states. Some patients also experience anxiety and depression due to a lack of timely and effective treatment for physical diseases, which makes depression increasingly prominent in patients with GU.
The relevant risk factors and pathogenesis of GU concomitant with depression have not yet been fully elucidated. The occurrence and severity of GU complicated with depression may be related to autoimmune dysfunction and gastro
This study aimed to investigate the immune function, gastrointestinal hormone levels, and clinical significance of patients with GU combined with depression and to control disease progression in patients with GU complicated with depression.
This study used a retrospective approach to analyze two indexes of immune function and gastrointestinal hormones. Fur
Serum immunoglobulin A (IgA), IgM, gastrin (GAS), and cholecystokinin (CCK) levels were the influencing factors affecting the severity of GU combined with depression; the area under the receiver operating characteristic curve of immune function (IgA, IgM) and gastrointestinal hormone levels (GAS, CCK) for the prediction of GU with depression severity was 0.958 (95% confidence interval: 0.933-0.976).
The occurrence of GU complicated with depression is related to autoimmune dysfunction and disorders of gastro
Using a retrospective analysis approach, patients were divided into severe and mild-moderate groups according to the Hamilton Depression Scale. Basic data from both groups, including immune function and gastrointestinal hormone markers, were used to analyze the factors affecting the severity of GU and concurrent depression. To explore the value of immune function indices, gastrointestinal hormone indices and a combination of indices were used to predict the severity of GU and depression.