Case Control Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Dec 19, 2023; 13(12): 1005-1015
Published online Dec 19, 2023. doi: 10.5498/wjp.v13.i12.1005
Haplotype analysis of long-chain non-coding RNA NONHSAT102891 promoter polymorphisms and depression in Chinese individuals: A case-control association study
Yue Li, Yi-Xi Wang, Xing-Ming Tang, Peng Liang, Jing-Jie Chen, Feng Jiang, Qiang Yang, Yun-Dan Liang
Yue Li, Yi-Xi Wang, Peng Liang, Jing-Jie Chen, Feng Jiang, Qiang Yang, Yun-Dan Liang, Department of Pathology and Pathophysiology, Chengdu Medical College, Chengdu 610500, Sichuan Province, China
Xing-Ming Tang, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Author contributions: Liang YD designed the study and corrected the manuscript; Li Y performed the majority of experiments and wrote the manuscript; Wang YX, Tang XM, Liang P, Chen JJ, Jiang F, Yang Q participated to the data collection and analysis of human material, and commented on previous versions of the manuscript; all authors contributed to the study conception and design. All authors read and approved the final manuscript.
Supported by National Natural Science Foundation of China, No. 81901379; Chengdu Medical College Graduate Research Innovation Fund Project, No. YCX2023-01-03; National Undergraduate Training Program for Innovation and Entrepreneurship, No. 202113705034.
Institutional review board statement: The study was approved by the ethics committee of Chengdu medical college (Chengdu, China) (approval number: 201815).
Informed consent statement: All patients gave informed consent.
Conflict-of-interest statement: Dr. Liang reports grants from the National Natural Science Foundation of China, grants from the Chengdu Medical College Graduate Research Innovation Fund Project, grants from the National Undergraduate Training Program for Innovation and Entrepreneurship, during the conduct of the study.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at liangyundan2004@126.com
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yun-Dan Liang, PhD, Adjunct Associate Professor, Associate Professor, Department of Pathology and Pathophysiology, Chengdu Medical College, No. 783 Xindu Avenue, Chengdu 610500, Sichuan Province, China. liangyundan2004@126.com
Received: August 31, 2023
Peer-review started: August 31, 2023
First decision: September 14, 2023
Revised: October 13, 2023
Accepted: November 9, 2023
Article in press: November 9, 2023
Published online: December 19, 2023
Processing time: 110 Days and 5.1 Hours
Core Tip

Core Tip: Depression has risen to the top of the global burden of non-fatal diseases. Recently, emerging evidence supports long-chain non-coding RNA (lncRNA) may be involved in the occurrence and development of depression, and may serve as potential diagnostic and prognostic markers. Our previous study showed lncRNA NONHSAT102891 rs155979 GC affects depression susceptibility; this study genotyped 480 depression patients and 329 healthy controls for the two single-nucleotide polymorphisms and made dual-luciferase reporter assays to explore and elucidate the function of the two lncRNA NONHSAT102891 promoter G/C and A/T haplotypes. We found the rs6230 and rs3792747 CG haplotypes may reduce the risk of depression, which expanded our knowledge about this disease.