Retrospective Cohort Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Sep 19, 2024; 14(9): 1319-1325
Published online Sep 19, 2024. doi: 10.5498/wjp.v14.i9.1319
Improving treatment plan and mental health in children with abdominal infection for broad-spectrum bacterial infections
Gui-Bo Wang, Xue-Feng Zhang, Bing Liang, Jie Lei, Jun Xue
Gui-Bo Wang, Xue-Feng Zhang, Bing Liang, Jie Lei, Department of Pediatric Surgery, the First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, Hebei Province, China
Jun Xue, Department of General Surgery, the First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, Hebei Province, China
Author contributions: Wang GB, Lei J, Xue J were the guarantors and designed the study; Wang GB, Liang B, Zhang XF participated in the acquisition, analysis, and interpretation of the data, and drafted the initial manuscript; Wang GB revised the article critically for important intellectual content.
Supported by Zhangjiakou Science and Technology Tackling Program, No. 2021099D.
Institutional review board statement: The study was reviewed and approved by the Science and Research Office of the First Affiliated Hospital of Hebei North University.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: There are no conflicts of interest to report.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Gui-Bo Wang, MM, Attending Doctor, Department of Pediatric Surgery, the First Affiliated Hospital of Hebei North University, No. 12 Changqing Road, Qiaoxi District, Zhangjiakou 075000, Hebei Province, China. heibaizhubobo@163.com
Received: July 24, 2024
Revised: August 14, 2024
Accepted: August 15, 2024
Published online: September 19, 2024
Processing time: 48 Days and 19.1 Hours
Abstract
BACKGROUND

Pediatric abdominal infection is a common but serious disease that requires timely and effective treatment. In surgical treatment, accurate diagnosis and rational application of antibiotics are the keys to improving treatment effects.

AIM

To investigate the effect of broad-spectrum bacterial detection on postoperative antibiotic therapy.

METHODS

A total of 100 children with abdominal infection who received surgical treatment in our hospital from September 2020 to July 2021 were grouped. The observation group collected blood samples upon admission and sent them for broad-spectrum bacterial infection nucleic acid testing, and collected pus or exudate during the operation for bacterial culture and drug sensitivity testing; the control group only sent bacterial culture and drug sensitivity testing during the operation.

RESULTS

White blood cell count, C-reactive protein, procalcitonin, 3 days after surgery, showed better postoperative index than the control group (P < 0.05). The hospital stay in the observation group was significantly shorter than that in the control group. The hospitalization cost in the observation group was significantly lower than that in the control group, and the difference between the two groups was statistically significant (P < 0.05).

CONCLUSION

Early detection of broad-spectrum bacterial infection nucleic acids in pediatric abdominal infections can help identify pathogens sooner and guide the appropriate use of antibiotics, improving treatment outcomes and reducing medical costs to some extent.

Keywords: Pediatric abdominal infection; Nucleic acid detection of broad-spectrum bacterial infection; Bacterial culture; Drug sensitivity testing; Treatment effect; Cost; Mental health

Core Tip: Preliminary nucleic acid detection of broad-spectrum bacterial infections has important clinical significance in the surgical treatment of abdominal infections in children. The results of this study show that compared with only intraoperative bacterial culture + drug sensitivity testing, early broad-spectrum bacterial infection nucleic acid testing can significantly improve patients' treatment effects, mental health and recovery quality, and reduce medical costs. First of all, conducting broad-spectrum bacterial infection nucleic acid detection in advance can help identify pathogens earlier and guide the rational use of antibiotics, thereby effectively controlling the development of infection. The postoperative infection indicators of the patients in the observation group were significantly lower than those of the control group, and the hospitalization time and costs were also significantly reduced, which further verified the clinical value of nucleic acid testing in advance. This research result has guiding significance for clinical practice and also provides an important reference for future related research.