Basic Study
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World J Exp Med. Mar 20, 2024; 14(1): 91271
Published online Mar 20, 2024. doi: 10.5493/wjem.v14.i1.91271
Hepatic and renal effects of oral stingless bee honey in a streptozotocin-induced diabetic rat model
Suriati Mohd Nasir, Anis Farihan Ismail, Tuan Salwani Tuan Ismail, Wan Faiziah Wan Abdul Rahman, Wan Amir Nizam Wan Ahmad, Tengku Ahmad Damitri Al- Astani Tengku Din, Kuttulebbai Nainamohammed Salam Sirajudeen
Suriati Mohd Nasir, Anis Farihan Ismail, Tengku Ahmad Damitri Al- Astani Tengku Din, Department of Chemical Pathology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu 16150, Kelantan, Malaysia
Tuan Salwani Tuan Ismail, Endocrinology Laboratory, Department of Chemical Pathology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu 16150, Kelantan, Malaysia
Wan Faiziah Wan Abdul Rahman, Department of Pathology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu 16150, Kelantan, Malaysia
Wan Amir Nizam Wan Ahmad, Biomedicine Program, School of Health Sciences, Health Campus, Universiti Sains Malaysia, Kota Bharu 16150, Kelantan, Malaysia
Kuttulebbai Nainamohammed Salam Sirajudeen, Department of Basic Medical Sciences, Kuliyyah of Medicine, International Islamic University Malaysia, Bandar Indera Mahkota, Kuantan 25200, Pahang, Malaysia
Author contributions: Mohd Nasir S and Ismail AF conducted animal study and laboratory analysis; Tuan Ismail TS and Sirajudeen KNS designed the study objective and methodology; Wan Ahmad WAN and Wan Abdul Rahman WF reviewed and validated the histological analysis; Tengku Din TADAA conducted statistical analysis and guided the animal and laboratory study; All the authors contributed to manuscript writing; Tuan Ismail TS edited and proofread the manuscripts.
Supported by Ministry of Higher Education, Malaysia for Fundamental Research Grant Scheme FRGS/1/2019/SKK06/USM/03/6, No. 291983-329281.
Institutional animal care and use committee statement: This study was approved by the Institutional Animal Care and Use Committee USM, Kubang Kerian [USM/IACUC/2019/(120) (1020)].
Conflict-of-interest statement: All the authors declare no conflict of interest in conducting this research.
Data sharing statement: No additional data is available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Tuan Salwani Tuan Ismail, MBBS, Associate Professor, Doctor, Endocrinology Laboratory, Department of Chemical Pathology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kota Bharu 16150, Kelantan, Malaysia. tusti@usm.my
Received: December 26, 2023
Peer-review started: December 26, 2023
First decision: January 11, 2024
Revised: January 24, 2024
Accepted: March 1, 2024
Article in press: March 1, 2024
Published online: March 20, 2024
Processing time: 84 Days and 8.3 Hours
Core Tip

Core Tip: Honey products are widely recognized for their abundant vitamin content and bioactive components, which enhance their potential therapeutic benefits in the management of diabetes. This study demonstrated the hepatic and renal protective properties of stingless bee honey, which improved the architecture of the kidney and liver in diabetic rats. Thus, stingless bee honey could be useful in the treatment or prevention of liver and kidney impairment in diabetes.