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©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Crit Care Med. Feb 4, 2016; 5(1): 36-46
Published online Feb 4, 2016. doi: 10.5492/wjccm.v5.i1.36
Published online Feb 4, 2016. doi: 10.5492/wjccm.v5.i1.36
Neuroprotective measures in children with traumatic brain injury
Shruti Agrawal, Ricardo Garcia Branco, Department of Paediatric Intensive Care, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, United Kingdom
Author contributions: Agrawal S did the research and drafted the article; Branco RG made critical revisions related to important intellectual content of the manuscript.
Conflict-of-interest statement: Agrawal S and Branco RG have no conflicts of interest to declare for this article.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Shruti Agrawal, MD, FRCPCH, FFICM, Department of Paediatric Intensive Care, Cambridge University Hospitals NHS Foundation Trust, Box 7, Addenbrookes Hospital, Hills Road, Cambridge CB2 0QQ, United Kingdom. shruti.agrawal@addenbrookes.nhs.uk
Telephone: +44-1223-348066 Fax: +44-1223-586794
Received: September 29, 2015
Peer-review started: October 2, 2015
First decision: October 27, 2015
Revised: December 1, 2015
Accepted: January 8, 2016
Article in press: January 11, 2016
Published online: February 4, 2016
Processing time: 116 Days and 9.8 Hours
Peer-review started: October 2, 2015
First decision: October 27, 2015
Revised: December 1, 2015
Accepted: January 8, 2016
Article in press: January 11, 2016
Published online: February 4, 2016
Processing time: 116 Days and 9.8 Hours
Core Tip
Core tip: Paediatric traumatic brain injury (TBI) causes significant morbidity and mortality. The modern management of severe TBI in children focuses on preventing secondary brain injury to improve outcome. In this article, we review the current management of severe TBI in children. We also review the recent advances in understanding intracranial physiology and neuroprotective therapies, advanced and multi-modal neuromonitoring, and potential new therapeutic and prognostic targets.