Meta-Analysis
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Crit Care Med. Sep 9, 2021; 10(5): 290-300
Published online Sep 9, 2021. doi: 10.5492/wjccm.v10.i5.290
Clinical benefits of corticosteroid administration during adult cardiopulmonary resuscitation: A systemic review and meta-analysis
Wachira Wongtanasarasin, Sarunsorn Krintratun
Wachira Wongtanasarasin, Sarunsorn Krintratun, Department of Emergency Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand
Author contributions: Wongtanasarasin W and Krintratun S designed the protocol, contributed to data collection and data analysis; Wongtanasarasin W contributed to the formal analysis and wrote the first draft of the manuscript; all authors read and critically reviewed the final version of the manuscript.
Conflict-of-interest statement: The authors declare that they have no competing interests.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wachira Wongtanasarasin, MD, Attending Doctor, Department of Emergency Medicine, Faculty of Medicine, Chiang Mai University, 110 Intavarorot Street, Sriphum, Chiang Mai 50200, Thailand. wachir_w@hotmail.com
Received: April 9, 2021
Peer-review started: April 9, 2021
First decision: July 27, 2021
Revised: July 28, 2021
Accepted: August 6, 2021
Article in press: August 6, 2021
Published online: September 9, 2021
Processing time: 153 Days and 8 Hours
Core Tip

Core Tip: Several studies have demonstrated that patients who receive steroids after achieving a return of spontaneous circulation (ROSC) had better outcomes. Few studies have investigated steroid administration during resuscitation, and the results are not clear. We conducted a systematic review and meta-analysis of the clinical benefits of steroids during cardiac arrest. The analysis included six studies and found that steroid administration during cardiac arrest was associated with better outcomes of resuscitation, including survival rate at hospital discharge, sustained ROSC, and favorable neurological outcome at hospital discharge.