Wongtanasarasin W, Krintratun S. Clinical benefits of corticosteroid administration during adult cardiopulmonary resuscitation: A systemic review and meta-analysis. World J Crit Care Med 2021; 10(5): 290-300 [PMID: 34616663 DOI: 10.5492/wjccm.v10.i5.290]
Corresponding Author of This Article
Wachira Wongtanasarasin, MD, Attending Doctor, Department of Emergency Medicine, Faculty of Medicine, Chiang Mai University, 110 Intavarorot Street, Sriphum, Chiang Mai 50200, Thailand. wachir_w@hotmail.com
Research Domain of This Article
Emergency Medicine
Article-Type of This Article
Meta-Analysis
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Crit Care Med. Sep 9, 2021; 10(5): 290-300 Published online Sep 9, 2021. doi: 10.5492/wjccm.v10.i5.290
Clinical benefits of corticosteroid administration during adult cardiopulmonary resuscitation: A systemic review and meta-analysis
Wachira Wongtanasarasin, Sarunsorn Krintratun
Wachira Wongtanasarasin, Sarunsorn Krintratun, Department of Emergency Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand
Author contributions: Wongtanasarasin W and Krintratun S designed the protocol, contributed to data collection and data analysis; Wongtanasarasin W contributed to the formal analysis and wrote the first draft of the manuscript; all authors read and critically reviewed the final version of the manuscript.
Conflict-of-interest statement: The authors declare that they have no competing interests.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wachira Wongtanasarasin, MD, Attending Doctor, Department of Emergency Medicine, Faculty of Medicine, Chiang Mai University, 110 Intavarorot Street, Sriphum, Chiang Mai 50200, Thailand. wachir_w@hotmail.com
Received: April 9, 2021 Peer-review started: April 9, 2021 First decision: July 27, 2021 Revised: July 28, 2021 Accepted: August 6, 2021 Article in press: August 6, 2021 Published online: September 9, 2021 Processing time: 153 Days and 8 Hours
ARTICLE HIGHLIGHTS
Research background
The clinical benefits of steroid administration during adult cardiac arrest remain controversial. According to the latest guidelines for managing adult cardiac arrest, steroid was not routinely recommended giving during resuscitation.
Research motivation
Previous studies have shown that patients who receive steroids after return of spontaneous circulation (ROSC) have improved outcomes. In contrast, few studies have investigated the benefits of steroid administration during resuscitation and the results are unclear.
Research objectives
The objectives of this review were to investigate the clinical benefits of steroids during adult cardiac arrest, including the survival rate at hospital discharge, sustained ROSC, the survival rate at hospital admission, and neurological outcome at hospital discharge.
Research methods
We conducted a systematic review and meta-analysis.
Research results
Steroid administration was associated with increased survival at hospital discharge. Steroid administration during cardiac arrest was associated with an increased rate of sustained ROSC and a favorable neurological outcome at hospital discharge.
Research conclusions
Although we could not draw firm conclusions, the use of steroids during cardiac arrest was associated with improved outcomes of resuscitation.
Research perspectives
Further study concerning the use of steroid in the prepared protocol and selected circumstances are warranted.
