Review
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Pediatr. Jun 9, 2024; 13(2): 91478
Published online Jun 9, 2024. doi: 10.5409/wjcp.v13.i2.91478
Assessing the impact of concurrent high-fructose and high-saturated fat diets on pediatric metabolic syndrome: A review
Manuel Alejandro Vargas-Vargas, Marcela González-Montoya, Olin Torres-Isidro, Claudia Isabel García-Berumen, Omar Ortiz-Avila, Elizabeth Calderón-Cortés, Christian Cortés-Rojo
Manuel Alejandro Vargas-Vargas, Marcela González-Montoya, Olin Torres-Isidro, Claudia Isabel García-Berumen, Christian Cortés-Rojo, Instituto de Investigaciones Químico – Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Morelia 58030, Michoacán, Mexico
Omar Ortiz-Avila, Elizabeth Calderón-Cortés, Facultad de Enfermería, Universidad Michoacana de San Nicolás de Hidalgo, Morelia 58020, Michoacán, Mexico
Author contributions: Cortés-Rojo C contributed to this paper with conception and design, literature review and analysis, manuscript drafting, critical revision, and editing; Vargas-Vargas MA, González-Montoya M, Torres-Isidro O and Ortiz-Avila O contributed to this paper with literature review and analysis, manuscript drafting and critical revision; García-Berumen CI and Calderón-Cortés E contributed to this paper with manuscript drafting, editing and critical revision; all authors have read and approved the final manuscript.
Supported by Instituto de Ciencia, Tecnología e Innovación – Gobierno del Estado de Michoacán, No. ICTI-PICIR23-063 and No. ICTI-PICIR23-028; and Programa Proyectos de Investigación financiados 2024, Coordinación de Investigación Científica, Universidad Michoacana de San Nicolás de Hidalgo, México.
Conflict-of-interest statement: Dr. Cortés-Rojo has nothing to disclose.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Christian Cortés-Rojo, BSc, MSc, PhD, Professor, Instituto de Investigaciones Químico – Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Edificio B-3, Ciudad Universitaria, Avenida Fco. J. Mujica, Morelia 58030, Michoacán, Mexico. christian.cortes@umich.mx
Received: December 29, 2023
Revised: April 22, 2024
Accepted: May 6, 2024
Published online: June 9, 2024
Processing time: 161 Days and 6.3 Hours
Core Tip

Core Tip: High-fructose (HFr) or high-fat (HF) intake favors metabolic syndrome (MetS) development by different mechanisms. When combined, HFr exacerbates the effects of HF, leading to a faster and more severe MetS development. Combined HF + HFr is usually present in ultra-processed foods. However, there is a lack of studies in the pediatric population evaluating the impact of restricting the combined intake of carbohydrates and fat in MetS. We reviewed the mechanisms by which HF + HFr produces more severe MetS to support the need for studies targeting the combined intake of HF + HFr in pediatric population to improve the outcomes of different interventions against MetS.