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World J Orthop. May 18, 2025; 16(5): 106377
Published online May 18, 2025. doi: 10.5312/wjo.v16.i5.106377
Advances in research of neutrophil extracellular trap formation in osteoarticular diseases
Guan-Jun Sun, Feng Xu, Xiao-Yi Jiao, Yi Yin
Guan-Jun Sun, Feng Xu, Xiao-Yi Jiao, Yi Yin, Department of Joint and Sports Medicine, Suining Central Hospital, Suining 629000, Sichuan Province, China
Co-corresponding authors: Guan-Jun Sun and Yi Yin.
Author contributions: Sun GJ contributed to the idea of the manuscript, the collection of the data, and the initial manuscript drafting; Yi Y contributed to the idea of the manuscript; Xu F and Jiao XY contributed to the revision of the manuscript; Sun GJ and Yin Y contributed equally to this work as co-corresponding authors.
Supported by 2024 Suining Health Science and Technology Plan Project, No. 24ZDJB03.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Guan-Jun Sun, MD, Chief Physician, Deputy Director, Department of Joint and Sports Medicine, Suining Central Hospital, No. 27 Dongping North Road, Hedong New District, Suining 629000, Sichuan Province, China. hxsungj@163.com
Received: February 28, 2025
Revised: March 27, 2025
Accepted: April 14, 2025
Published online: May 18, 2025
Processing time: 78 Days and 0.7 Hours
Core Tip

Core Tip: Neutrophil extracellular traps contribute to the development of inflammatory and immune diseases, and this particular mechanism opens up a new field for understanding the pathogenesis of osteoarthrosis. This article reviews the research progress of neutrophil extracellular traps in common osteoarticular diseases. In-depth study of them can help reveal the underlying pathophysiological processes of osteoarthrosis and provide a theoretical basis for the development of new diagnostic markers and therapeutic targets.