Sun GJ, Xu F, Jiao XY, Yin Y. Advances in research of neutrophil extracellular trap formation in osteoarticular diseases. World J Orthop 2025; 16(5): 106377 [DOI: 10.5312/wjo.v16.i5.106377]
Corresponding Author of This Article
Guan-Jun Sun, MD, Chief Physician, Deputy Director, Department of Joint and Sports Medicine, Suining Central Hospital, No. 27 Dongping North Road, Hedong New District, Suining 629000, Sichuan Province, China. hxsungj@163.com
Research Domain of This Article
Orthopedics
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Orthop. May 18, 2025; 16(5): 106377 Published online May 18, 2025. doi: 10.5312/wjo.v16.i5.106377
Advances in research of neutrophil extracellular trap formation in osteoarticular diseases
Guan-Jun Sun, Feng Xu, Xiao-Yi Jiao, Yi Yin
Guan-Jun Sun, Feng Xu, Xiao-Yi Jiao, Yi Yin, Department of Joint and Sports Medicine, Suining Central Hospital, Suining 629000, Sichuan Province, China
Co-corresponding authors: Guan-Jun Sun and Yi Yin.
Author contributions: Sun GJ contributed to the idea of the manuscript, the collection of the data, and the initial manuscript drafting; Yi Y contributed to the idea of the manuscript; Xu F and Jiao XY contributed to the revision of the manuscript; Sun GJ and Yin Y contributed equally to this work as co-corresponding authors.
Supported by 2024 Suining Health Science and Technology Plan Project, No. 24ZDJB03.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Guan-Jun Sun, MD, Chief Physician, Deputy Director, Department of Joint and Sports Medicine, Suining Central Hospital, No. 27 Dongping North Road, Hedong New District, Suining 629000, Sichuan Province, China. hxsungj@163.com
Received: February 28, 2025 Revised: March 27, 2025 Accepted: April 14, 2025 Published online: May 18, 2025 Processing time: 78 Days and 0.7 Hours
Abstract
Neutrophil extracellular traps (NETs) have been the subject of research in the field of innate immunity since they were first described two decades ago. NETs are fibrous network structures released by neutrophils under specific stimuli, including DNA, histones, and a variety of granular proteins. NETs have been widely studied in the fields of infectious and immune diseases, and new breakthroughs have been made in the understanding of disease pathogenesis and treatment. In recent years, studies have found that NETs play an important role in the occurrence and development of osteoarticular diseases. This article reviews the progress in the research of NETs in common osteoarticular diseases such as rheumatoid arthritis, ankylosing spondylitis, gouty arthritis, osteonecrosis of the femoral head, osteoarthritis, and joint fibrosis, including the formation mechanism of NETs and its role in inflammation, joint destruction, pain and other pathological processes. The problems existing in current research are discussed, along with future research directions, to provide a reference for the in-depth study of osteoarticular diseases and the development of new treatment strategies.
Core Tip: Neutrophil extracellular traps contribute to the development of inflammatory and immune diseases, and this particular mechanism opens up a new field for understanding the pathogenesis of osteoarthrosis. This article reviews the research progress of neutrophil extracellular traps in common osteoarticular diseases. In-depth study of them can help reveal the underlying pathophysiological processes of osteoarthrosis and provide a theoretical basis for the development of new diagnostic markers and therapeutic targets.
