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World J Orthop. Mar 18, 2025; 16(3): 102274
Published online Mar 18, 2025. doi: 10.5312/wjo.v16.i3.102274
Cross-talks between osteoporosis and gut microbiome
Shiva Shankar Jha, Naveen Jeyaraman, Madhan Jeyaraman, Swaminathan Ramasubramanian, Sathish Muthu, Gabriel Silva Santos, Lucas Furtado da Fonseca, José Fábio Lana
Shiva Shankar Jha, Department of Orthopaedics, Harishchandra Orthopaedic Research Institute, Patna 880023, Bihar, India
Naveen Jeyaraman, Madhan Jeyaraman, Department of Orthopaedics, ACS Medical College and Hospital, Dr MGR Educational and Research Institute, Chennai 600077, Tamil Nadu, India
Naveen Jeyaraman, Madhan Jeyaraman, Sathish Muthu, Department of Orthopaedics, Orthopaedic Research Group, Coimbatore 641045, Tamil Nadu, India
Madhan Jeyaraman, Gabriel Silva Santos, Lucas Furtado da Fonseca, José Fábio Lana, Department of Orthopaedics, Brazilian Institute of Regenerative Medicine (BIRM), Indaiatuba 13334-170, São Paulo, Brazil
Swaminathan Ramasubramanian, Department of Orthopaedics, Government Medical College, Omandurar Government Estate, Chennai 600002, Tamil Nadu, India
Sathish Muthu, Department of Orthopaedics, Government Medical College and Hospital, Karur 639004, Tamil Nadu, India
Sathish Muthu, Department of Biotechnology, Faculty of Engineering, Karpagam Academy of Higher Education, Coimbatore 641021, Tamil Nadu, India
Co-first authors: Shiva Shankar Jha and Naveen Jeyaraman.
Author contributions: Jha SS contributed to acquiring clinical data and performing the data analysis; Jha SS, Jeyaraman N, and Jeyaraman M contributed to conceptualization; Jha SS, Jeyaraman N, and Ramasubramanian S contributed to manuscript writing; Jeyaraman M contributed to proofreading; Jeyaraman M, Santos GS, da Fonseca LF, and Lana JF helped in manuscript revision; Jeyaraman M and Lana JF contributed to administration; Muthu S contributed for image acquisition; all authors have agreed to the final version to be published and agree to be accountable for all aspects of the work.
Conflict-of-interest statement: All authors declare no conflict of interest in publishing the manuscript.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Madhan Jeyaraman, MD, PhD, Assistant Professor, Department of Orthopaedics, ACS Medical College and Hospital, Dr MGR Educational and Research Institute, Velappanchavadi, Chennai 600077, Tamil Nadu, India. madhanjeyaraman@gmail.com
Received: October 13, 2024
Revised: January 6, 2025
Accepted: February 6, 2025
Published online: March 18, 2025
Processing time: 149 Days and 14.8 Hours
Core Tip

Core Tip: Gut microbiota significantly influences bone health, with dysbiosis linked to osteoporosis. Emerging research highlights the potential of microbiota-targeted therapies, including probiotics and fecal microbiota transplantation, for osteoporosis management. However, challenges like mechanistic understanding and translation to human applications persist. Future research should focus on personalized approaches and multi-omics integration to develop effective microbiome-based treatments for bone health.