Cross-talks between osteoporosis and gut microbiome

Abstract

The gut microbiome comprises a vast community of microbes inhabiting the human alimentary canal, playing a crucial role in various physiological functions. These microbes generally live in harmony with the host; however, when dysbiosis occurs, it can contribute to the pathogenesis of diseases, including osteoporosis. Osteoporosis, a systemic skeletal disease characterized by reduced bone mass and increased fracture risk, has attracted significant research attention concerning the role of gut microbes in its development. Advances in molecular biology have highlighted the influence of gut microbiota on osteoporosis through mechanisms involving immunoregulation, modulation of the gut-brain axis, and regulation of the intestinal barrier and nutrient absorption. These microbes can enhance bone mass by inhibiting osteoclast differentiation, inducing apoptosis, reducing bone resorption, and promoting osteoblast proliferation and maturation. Despite these promising findings, the therapeutic effectiveness of targeting gut microbes in osteoporosis requires further investigation. Notably, gut microbiota has been increasingly studied for their potential in early diagnosis, intervention, and as an adjunct therapy for osteoporosis, suggesting a growing utility in improving bone health. Further research is essential to fully elucidate the therapeutic potential and clinical application of gut microbiome modulation in the management of osteoporosis.

Keywords: Microbiome; Dysbiosis; Osteoporosis; Prebiotics; Probiotics; Inflammation; Bile; Vitamin D; Calcium

Core Tip: Gut microbiota significantly influences bone health, with dysbiosis linked to osteoporosis. Emerging research highlights the potential of microbiota-targeted therapies, including probiotics and fecal microbiota transplantation, for osteoporosis management. However, challenges like mechanistic understanding and translation to human applications persist. Future research should focus on personalized approaches and multi-omics integration to develop effective microbiome-based treatments for bone health.