Effect of weight-adjusted antimicrobial antibiotic prophylaxis on postoperative dosage and surgical site infection incidence in total joint arthroplasty

doi:10.5312/wjo.v15.i4.318

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Apr 18, 2024 (publication date) through Apr 30, 2024

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World Journal of Orthopedics

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2218-5836

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Editorial

World J Orthop. Apr 18, 2024; 15(4): 318-320
Published online Apr 18, 2024. doi: 10.5312/wjo.v15.i4.318

Effect of weight-adjusted antimicrobial antibiotic prophylaxis on postoperative dosage and surgical site infection incidence in total joint arthroplasty

Ashim Gupta, Vijay Kumar Jain

Ashim Gupta, Department of Orthopaedics and Regenerative Medicine, Future Biologics, Lawrenceville, GA 30043, United States

Ashim Gupta, Department of Orthopaedics, South Texas Orthopaedic Research Institute (STORI Inc.), Laredo, TX 78045, United States

Ashim Gupta, Department of Regenerative Medicine, BioIntegrate, Lawrenceville, GA 30043, United States

Ashim Gupta, Department of Orthopaedics and Regenerative Medicine, Regenerative Orthopaedics, Noida 201301, India

Vijay Kumar Jain, Department of Orthopaedics, Atal Bihari Vajpayee Institute of Medical Sciences, Dr Ram Manohar Lohia Hospital, New Delhi 110001, India

Author contributions: Gupta A and Jain VK conceptualized the study and drafted, critically reviewed, and edited the manuscript. All authors approved the final version of the article for publication.

Conflict-of-interest statement: The authors declare having no conflicts of interests.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Ashim Gupta, MS, PhD, MBA, DABRM, FABRM, Founder and CEO, President, Professor, Department of Orthopaedics and Regenerative Medicine, Future Biologics, 2505 Newpoint Pkwy, Lawrenceville, GA 30043, United States. ashim6786@gmail.com

Received: January 8, 2024
Peer-review started: January 8, 2024
First decision: January 28, 2024
Revised: January 29, 2024
Accepted: March 1, 2024
Article in press: March 1, 2024
Published online: April 18, 2024

Core Tip

Core Tip: This editorial emphasized the evaluation of the efficacy of a weight-adjusted antimicrobial antibiotic prophylaxis regime on the incidence of surgical site infections and postoperative dosage reduction compared to a conventionally used regime during total joint arthroplasty. The results demonstrated similar efficacy between both regimes with respect to the incidence of surgical site infection. In addition, weight-adjustment led to reduced postoperative dosage and has the potential to reduce chances of achieving lower therapeutic concentration, drug resistance, drug toxicity, and costs.