Gupta A, Jain VK. Effect of weight-adjusted antimicrobial antibiotic prophylaxis on postoperative dosage and surgical site infection incidence in total joint arthroplasty. World J Orthop 2024; 15(4): 318-320 [PMID: 38680674 DOI: 10.5312/wjo.v15.i4.318]
Corresponding Author of This Article
Ashim Gupta, MS, PhD, MBA, DABRM, FABRM, Founder and CEO, President, Professor, Department of Orthopaedics and Regenerative Medicine, Future Biologics, 2505 Newpoint Pkwy, Lawrenceville, GA 30043, United States. ashim6786@gmail.com
Research Domain of This Article
Orthopedics
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Orthop. Apr 18, 2024; 15(4): 318-320 Published online Apr 18, 2024. doi: 10.5312/wjo.v15.i4.318
Effect of weight-adjusted antimicrobial antibiotic prophylaxis on postoperative dosage and surgical site infection incidence in total joint arthroplasty
Ashim Gupta, Vijay Kumar Jain
Ashim Gupta, Department of Orthopaedics and Regenerative Medicine, Future Biologics, Lawrenceville, GA 30043, United States
Ashim Gupta, Department of Orthopaedics, South Texas Orthopaedic Research Institute (STORI Inc.), Laredo, TX 78045, United States
Ashim Gupta, Department of Regenerative Medicine, BioIntegrate, Lawrenceville, GA 30043, United States
Ashim Gupta, Department of Orthopaedics and Regenerative Medicine, Regenerative Orthopaedics, Noida 201301, India
Vijay Kumar Jain, Department of Orthopaedics, Atal Bihari Vajpayee Institute of Medical Sciences, Dr Ram Manohar Lohia Hospital, New Delhi 110001, India
Author contributions: Gupta A and Jain VK conceptualized the study and drafted, critically reviewed, and edited the manuscript. All authors approved the final version of the article for publication.
Conflict-of-interest statement: The authors declare having no conflicts of interests.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ashim Gupta, MS, PhD, MBA, DABRM, FABRM, Founder and CEO, President, Professor, Department of Orthopaedics and Regenerative Medicine, Future Biologics, 2505 Newpoint Pkwy, Lawrenceville, GA 30043, United States. ashim6786@gmail.com
Received: January 8, 2024 Peer-review started: January 8, 2024 First decision: January 28, 2024 Revised: January 29, 2024 Accepted: March 1, 2024 Article in press: March 1, 2024 Published online: April 18, 2024 Processing time: 98 Days and 15.7 Hours
Abstract
Surgical site infections (SSI) following total joint arthroplasty pose a significant concern for both providers and patients across the globe. Currently, administration of antimicrobial antibiotic prophylaxis is used throughout the world to reduce the incidence of SSI. However, the correct dosage and frequency of administration remains debatable. In this editorial, we emphasized the determination of the effect of administration of weight-adjusted antimicrobial antibiotic prophylaxis regime on the incidence of SSI and postoperative dosage reduction compared to the conventionally used regime during total joint arthroplasty. The results demonstrated similar efficacy between both regimes with respect to the incidence of SSI. In addition, weight-adjustment led to reduced postoperative dosage and has the potential to reduce chances of achieving lower therapeutic concentration, drug resistance, drug toxicity, and costs.
Core Tip: This editorial emphasized the evaluation of the efficacy of a weight-adjusted antimicrobial antibiotic prophylaxis regime on the incidence of surgical site infections and postoperative dosage reduction compared to a conventionally used regime during total joint arthroplasty. The results demonstrated similar efficacy between both regimes with respect to the incidence of surgical site infection. In addition, weight-adjustment led to reduced postoperative dosage and has the potential to reduce chances of achieving lower therapeutic concentration, drug resistance, drug toxicity, and costs.
