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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
Comparative study in vivo of the osseointegration of 3D-printed and plasma-coated titanium implants
Stanislav Bondarenko, Volodymyr Filipenko, Nataliya Ashukina, Valentyna Maltseva, Gennadiy Ivanov, Iurii Lazarenko, Dmytro Sereda, Ran Schwarzkopf
Stanislav Bondarenko, Volodymyr Filipenko, Department of Joint Pathology, Sytenko Institute of Spine and Joint Pathology National Academy of Medical Sciences of Ukraine, Kharkiv 61024, Ukraine
Nataliya Ashukina, Valentyna Maltseva, Laboratory of Connective Tissue Morphology, Sytenko Institute of Spine and Joint Pathology National Academy of Medical Sciences of Ukraine, Kharkiv 61024, Ukraine
Gennadiy Ivanov, Experimental Pathology, Sytenko Institute of Spine and Joint Pathology National Academy of Medical Sciences of Ukraine, Kharkiv 61024, Ukraine
Iurii Lazarenko, Department of Traumatology, Military medical clinical center of the Central region, Vinnytsia 21018, Ukraine
Dmytro Sereda, Department of Surgery, Odesa city hospital 11, Odesa 65006, Ukraine
Ran Schwarzkopf, Hospital for Joint Diseases, NYU Langone Orthopedic Hospital, NY 10003, United States
Author contributions: All authors contributed to the study conception and design; Bondarenko S, Maltseva V and Ashukina N wrote the first draft version of the manuscript; Filipenko V supervised the study and performed critical revision of the article; Maltseva V performed data analysis and interpretation; Ivanov G, Lazarenko I and Sereda D performed experimental surgery, collection and interpretation data; Schwarzkopf R performed critical revision of the article; all authors revised and approved the final version of the manuscript.
Institutional review board statement: The study was reviewed and approved by the Sytenko Institute of Spine and Joint Pathology Review Board.
Institutional animal care and use committee statement: All applicable national guidelines for the care and use of animals were followed. The in vivo study was approved by the Ethical Clearance Bioethics Committee State Institution (Sytenko Institute of Spine and Joint Pathology NAMS of Ukraine), Kharkiv, Ukraine (protocol number 211 of 01 Feb 2021).
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
https://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Stanislav Bondarenko, DSc, MD, PhD, Associate Professor, Department of Joint Pathology, Sytenko Institute of Spine and Joint Pathology National Academy of Medical Sciences of Ukraine, 80 Pushkinska St., Kharkiv 61024, Ukraine. bondarenke@gmail.com
Received: May 12, 2023
Peer-review started: May 12, 2023
First decision: July 19, 2023
Revised: July 26, 2023
Accepted: August 7, 2023
Article in press: August 7, 2023
Published online: September 18, 2023
Processing time: 124 Days and 23 Hours
ARTICLE HIGHLIGHTS
Research background
Total hip arthroplasty is a common surgical treatment for elderly patients with osteoporosis and further discussion is needed if use of such acetabular components is justified under the condition of normal bone mass.
Research motivation
There is a need to perform studies to compare of osseintegration of two different types of titanium implants [3-dimensional (3D)-printed and plasma-coated titanium implants].
Research objectives
To determine the features of osseointegration of two different types of titanium implants (3D-printed and plasma-coated titanium implants) in bone tissue of a distal metaphysis in a rat femur model.
Research methods
This study was performed in a rat femur model. Histological examination of the femur was carried out by measuring the relative perimeter of bone trabeculae [bone-implant contact (BIC%)] and bone marrow surrounding of 3D-printed titanium implant (highly porous) and plasma-coated titanium implant.
Research results
Trabecular bone tissue was formed on the 45th day after implantation around the implants regardless of their type. Forty-five days after surgery groups with different implants did not differ in BIC%, but after 90 d, the BIC% was higher in 3D-printed titanium implant group.
Research conclusions
The use of a highly porous titanium implant, manufactured with 3D printing, for acetabular components provides increased osseointegration compared to a plasma-coated titanium implant.
Research perspectives
Further research studies on the use of other histological and biomechanical methods will help to determine the optimal materials of acetabular implants in terms of structure and complexity of their manufacture to be used in patients with normal bone mass.
