Bondarenko S, Filipenko V, Ashukina N, Maltseva V, Ivanov G, Lazarenko I, Sereda D, Schwarzkopf R. Comparative study in vivo of the osseointegration of 3D-printed and plasma-coated titanium implants. World J Orthop 2023; 14(9): 682-689 [PMID: 37744721 DOI: 10.5312/wjo.v14.i9.682]
Corresponding Author of This Article
Stanislav Bondarenko, DSc, MD, PhD, Associate Professor, Department of Joint Pathology, Sytenko Institute of Spine and Joint Pathology National Academy of Medical Sciences of Ukraine, 80 Pushkinska St., Kharkiv 61024, Ukraine. bondarenke@gmail.com
Research Domain of This Article
Orthopedics
Article-Type of This Article
Basic Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Orthop. Sep 18, 2023; 14(9): 682-689 Published online Sep 18, 2023. doi: 10.5312/wjo.v14.i9.682
Comparative study in vivo of the osseointegration of 3D-printed and plasma-coated titanium implants
Stanislav Bondarenko, Volodymyr Filipenko, Nataliya Ashukina, Valentyna Maltseva, Gennadiy Ivanov, Iurii Lazarenko, Dmytro Sereda, Ran Schwarzkopf
Stanislav Bondarenko, Volodymyr Filipenko, Department of Joint Pathology, Sytenko Institute of Spine and Joint Pathology National Academy of Medical Sciences of Ukraine, Kharkiv 61024, Ukraine
Nataliya Ashukina, Valentyna Maltseva, Laboratory of Connective Tissue Morphology, Sytenko Institute of Spine and Joint Pathology National Academy of Medical Sciences of Ukraine, Kharkiv 61024, Ukraine
Gennadiy Ivanov, Experimental Pathology, Sytenko Institute of Spine and Joint Pathology National Academy of Medical Sciences of Ukraine, Kharkiv 61024, Ukraine
Iurii Lazarenko, Department of Traumatology, Military medical clinical center of the Central region, Vinnytsia 21018, Ukraine
Dmytro Sereda, Department of Surgery, Odesa city hospital 11, Odesa 65006, Ukraine
Ran Schwarzkopf, Hospital for Joint Diseases, NYU Langone Orthopedic Hospital, NY 10003, United States
Author contributions: All authors contributed to the study conception and design; Bondarenko S, Maltseva V and Ashukina N wrote the first draft version of the manuscript; Filipenko V supervised the study and performed critical revision of the article; Maltseva V performed data analysis and interpretation; Ivanov G, Lazarenko I and Sereda D performed experimental surgery, collection and interpretation data; Schwarzkopf R performed critical revision of the article; all authors revised and approved the final version of the manuscript.
Institutional review board statement: The study was reviewed and approved by the Sytenko Institute of Spine and Joint Pathology Review Board.
Institutional animal care and use committee statement: All applicable national guidelines for the care and use of animals were followed. The in vivo study was approved by the Ethical Clearance Bioethics Committee State Institution (Sytenko Institute of Spine and Joint Pathology NAMS of Ukraine), Kharkiv, Ukraine (protocol number 211 of 01 Feb 2021).
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Stanislav Bondarenko, DSc, MD, PhD, Associate Professor, Department of Joint Pathology, Sytenko Institute of Spine and Joint Pathology National Academy of Medical Sciences of Ukraine, 80 Pushkinska St., Kharkiv 61024, Ukraine. bondarenke@gmail.com
Received: May 12, 2023 Peer-review started: May 12, 2023 First decision: July 19, 2023 Revised: July 26, 2023 Accepted: August 7, 2023 Article in press: August 7, 2023 Published online: September 18, 2023 Processing time: 124 Days and 23 Hours
Abstract
BACKGROUND
Total hip arthroplasty is a common surgical treatment for elderly patients with osteoporosis, particularly in postmenopausal women. In such cases, highly porous acetabular components are a favorable option in achieving osseointegration. However, further discussion is needed if use of such acetabular components is justified under the condition of normal bone mass.
AIM
To determine the features of osseointegration of two different types of titanium implants [3-dimensional (3D)-printed and plasma-coated titanium implants] in bone tissue of a distal metaphysis in a rat femur model.
METHODS
This study was performed on 20 white male laboratory rats weighing 300-350 g aged 6 mo. Rats were divided into two groups of 10 animals, which had two different types of implants were inserted into a hole defect (2 × 3 mm) in the distal metaphysis of the femur: Group I: 3D-printed titanium implant (highly porous); Group II: Plasma-coated titanium implant. After 45 and 90 d following surgery, the rats were sacrificed, and their implanted femurs were extracted for histological examination. The relative perimeter (%) of bone trabeculae [bone-implant contact (BIC%)] and bone marrow surrounding the titanium implants was measured.
RESULTS
Trabecular bone tissue was formed on the 45th day after implantation around the implants regardless of their type. 45 d after surgery, group I (3D-printed titanium implant) and group II (plasma-coated titanium implant) did not differ in BIC% (83.51 ± 8.5 vs 84.12 ± 1 .73; P = 0.838). After 90 d, the BIC% was higher in group I (87.04 ± 6.99 vs 81.24 ± 7.62; P = 0.049), compared to group II. The relative perimeter of the bone marrow after 45 d did not differ between groups and was 16.49% ± 8.58% for group I, and 15.88% ± 1.73% for group II. Futhermore, after 90 d, in group I the relative perimeter of bone marrow was 1.4 times smaller (12.96 ± 6.99 vs 18.76 ± 7.62; P = 0.049) compared to the relative perimeter of bone marrow in group II.
CONCLUSION
The use of a highly porous titanium implant, manufactured with 3D printing, for acetabular components provides increased osseointegration compared to a plasma-coated titanium implant.
Core Tip: The use of porous titanium materials was shown to be the most favorable solution for osseointegration for total hip arthroplasty, especially in the case of osteoporosis. Is the use of highly porous acetabular components justified under the condition of normal bone mass? We conducted a study on rats, in which we compared the osseointegration of 3-dimensional (3D)-printed or plasma-coated titanium implants into femoral bone defect by assessing the relative perimeter (%) of bone trabeculae. The highly porous titanium implant, manufactured with 3-dimensional printing, for acetabular components provides increased osseointegration compared to a plasma-coated titanium implant.
