Pastides PS, Welck MJ, Khan WS. Use of bone marrow derived stem cells in trauma and orthopaedics: A review of current concepts. World J Orthop 2015; 6(6): 462-468 [PMID: 26191493 DOI: 10.5312/wjo.v6.i6.462]
Corresponding Author of This Article
Wasim S Khan, MBChB, MSc, PhD, FRCS (Tr and Orth), Orthopaedic Registrar, Clinical Lecturer, University College London Institute of Orthopaedics and Musculoskeletal Sciences, Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, Middlesex HA7 4LP, United Kingdom. wasimkhan@doctors.org.uk
Research Domain of This Article
Orthopedics
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Orthop. Jul 18, 2015; 6(6): 462-468 Published online Jul 18, 2015. doi: 10.5312/wjo.v6.i6.462
Use of bone marrow derived stem cells in trauma and orthopaedics: A review of current concepts
Philip S Pastides, Matthew J Welck, Wasim S Khan
Philip S Pastides, Wasim S Khan, University College London Institute of Orthopaedics and Musculoskeletal Sciences, Royal National Orthopaedic Hospital, Stanmore, Middlesex HA7 4LP, United Kingdom
Matthew J Welck, Wexham Park Hospital, Slough, West Berkshire SL2 4HL, United Kingdom
Author contributions: Pastides PS, Welck MJ and Khan WS all collected, wrote, edited and approved the final version of the manuscript.
Conflict-of-interest statement: The authors declare no conflicting interests attached to this article.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Wasim S Khan, MBChB, MSc, PhD, FRCS (Tr and Orth), Orthopaedic Registrar, Clinical Lecturer, University College London Institute of Orthopaedics and Musculoskeletal Sciences, Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, Middlesex HA7 4LP, United Kingdom. wasimkhan@doctors.org.uk
Telephone: +44-20-889542300 Fax: +44-20-7679200
Received: February 8, 2015 Peer-review started: February 9, 2015 First decision: April 10, 2015 Revised: May 7, 2015 Accepted: May 27, 2015 Article in press: May 28, 2015 Published online: July 18, 2015 Processing time: 155 Days and 20.9 Hours
Abstract
There is a considerable amount of interest in the future role of bone marrow-derived stem cells (BMDSCs) and tissue engineering techniques to manage conditions within the musculoskeletal system. Repair of soft tissue and bone defects, in the early stages of injury, may lead to a reduction in progression of symptoms. Furthermore, troublesome soft tissue injuries that are notoriously fraught with problems either in healing or function, could be augmented with such techniques. The aim of this review paper is to look at the advances in such strategies to tackle these problems and assess how BMDSCs, with the aid of growth factors and scaffolds, are being used in vitro, animal and even human models to treat problems within the field of trauma and orthopaedics. There is plenty of evidence that the results are encouraging and thus gaining momentum toward their use in human studies.
Core tip: Tissue engineering techniques using bone marrow-derived stem cells is an attractive, promising and growing area of research within the field of trauma and orthopaedics. There are plenty of in vitro and animal studies showing the benefits of such treatments with a slow and steady growth of human in vivo studies emerging.
