Long non-coding RNA in the regulation of cell death in hepatocellular carcinoma

Table 1 Abnormal long non-coding RNA studies associated with hepatocellular carcinoma cell death

Type	Ref.	Year	Findings
Necroptosis	Peng et al[54]	2022	Ten candidate lncRNAs were obtained, from which a prognostic risk model was constructed. The patients with high-risk scores have lower survival rates
	Chen et al[56]	2022	A 6-lncRNA prediction models have good prognostic value for liver cancer, and are worthy of clinical application
	Wang et al[57]	2022	A model containing four necrotic apoptoses-associated lncRNAs was constructed. The OS of low-risk patients is significantly longer than that of high-risk patients
	Chen et al[58]	2024	A positive correlation was observed between the five necrosis-associated lncRNA and the malignant phenotypes of HCC
Apoptosis	Hussain et al[70]	2023	NEAT1 has the ability to inhibit the proliferation, migration and invasion of cancer cells in HCC and promote apoptosis
	Yao et al[71]	2021	LncRNA CASC9 promotes proliferation, migration and inhibits apoptosis of hepatocellular carcinoma cells by down-regulating miR-424-5p
	Cai et al[72]	2021	LncRNA AIRN influences the proliferation and apoptosis of hepatocellular carcinoma cells by regulating STAT1 ubiquitination
	Fei et al[73]	2020	LncRNA ST8SIA6-AS1 promotes hepatocellular carcinoma cell proliferation and resistance to apoptosis by targeting miR-4656/HDAC11 axis
Ferroptosis	Xu et al[83]	2021	A nine-lncRNA-based signature was identified as the ferroptosis-related prognostic model for HCC, independent of multiple clinicopathological parameters
	Zhang et al[84]	2022	LncRNA HEPFAL accelerates ferroptosis in hepatocellular carcinoma by regulating SLC7A11 ubiquitination
Pyroptosis	Wu et al[93]	2023	These prognosis-related lncRNAs, miRNAs, and PRGs formed eleven lncRNA-miRNA-mRNA regulatory axes
Autophagy	Braconi et al[101]	2011	The resistance of HCC to lenvatinib was influenced by the regulatory axis of HOTAIRM1-miR-34a-Beclin-1
Cuproptosis	Li et al[108]	2023	The expression of copper poisoning gene CDKN2A was closely positively associated with lncRNA DDX 11-AS 1

lncRNA: Long non-coding RNA; HCC: Hepatocellular carcinoma; OS: Overall survival.