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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Apr 24, 2025; 16(4): 104061
Published online Apr 24, 2025. doi: 10.5306/wjco.v16.i4.104061
Published online Apr 24, 2025. doi: 10.5306/wjco.v16.i4.104061
Long non-coding RNA in the regulation of cell death in hepatocellular carcinoma
Jiang Wang, Zi-Xuan Liu, Zhi-Hong Huang, Children Medical Center, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha 410013, Hunan Province, China
Jie Wen, Department of Pediatric Orthopedics, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha 410013, Hunan Province, China
Zhou-Zhou Rao, Department of Physiology, Hunan Normal University School of Medicine, Changsha 410003, Hunan Province, China
Co-first authors: Jiang Wang and Zi-Xuan Liu.
Co-corresponding authors: Jie Wen and Zhou-Zhou Rao.
Author contributions: Wang J conceived and coordinated the study; Liu ZX designed the study; Huang ZH performed and analyzed the literature; Wen J performed the database search; Rao ZZ applied for and obtained the funds for this research project; All authors reviewed the results and approved the final version of the manuscript. Wang J and Liu ZX have made crucial and indispensable contributions towards the completion of the project and thus qualified as the co-first authors of the paper. Wen J and Rao ZZ have played important and indispensable roles in the database search and manuscript preparation as the co-corresponding authors.
Supported by Science Project of Hunan Provincial Healthy Commission, No. 20230844.
Conflict-of-interest statement: The authors declare that they have no competing interests.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jie Wen, PhD, Associate Professor, Department of Pediatric Ortho
Received: December 9, 2024
Revised: February 2, 2025
Accepted: February 25, 2025
Published online: April 24, 2025
Processing time: 107 Days and 22.4 Hours
Revised: February 2, 2025
Accepted: February 25, 2025
Published online: April 24, 2025
Processing time: 107 Days and 22.4 Hours
Core Tip
Core Tip: The molecular mechanisms underlying hepatocellular carcinoma (HCC) development remain challenging to fully elucidate. The advent of high-throughput sequencing technologies has revealed that long non-coding RNAs (lncRNAs) play a pivotal role in gene regulation, contributing to cell proliferation, inhibiting apoptosis, promoting invasion and metastasis, and modulating metabolic processes. Dysregulation of lncRNAs is intricately linked to the progression of HCC, indicating their potential as prognostic markers and therapeutic targets. In this review, we systematically examine the research progress on lncRNA-mediated regulation of HCC cell death and discuss its potential therapeutic applications.