Wang J, Liu ZX, Huang ZH, Wen J, Rao ZZ. Long non-coding RNA in the regulation of cell death in hepatocellular carcinoma. World J Clin Oncol 2025; 16(4): 104061 [DOI: 10.5306/wjco.v16.i4.104061]
Corresponding Author of This Article
Jie Wen, PhD, Associate Professor, Department of Pediatric Orthopedics, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, No. 61 West Jiefang Road, Changsha 410013, Hunan Province, China. cashwj@qq.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Oncol. Apr 24, 2025; 16(4): 104061 Published online Apr 24, 2025. doi: 10.5306/wjco.v16.i4.104061
Long non-coding RNA in the regulation of cell death in hepatocellular carcinoma
Jiang Wang, Zi-Xuan Liu, Zhi-Hong Huang, Jie Wen, Zhou-Zhou Rao
Jiang Wang, Zi-Xuan Liu, Zhi-Hong Huang, Children Medical Center, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha 410013, Hunan Province, China
Jie Wen, Department of Pediatric Orthopedics, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha 410013, Hunan Province, China
Zhou-Zhou Rao, Department of Physiology, Hunan Normal University School of Medicine, Changsha 410003, Hunan Province, China
Co-first authors: Jiang Wang and Zi-Xuan Liu.
Co-corresponding authors: Jie Wen and Zhou-Zhou Rao.
Author contributions: Wang J conceived and coordinated the study; Liu ZX designed the study; Huang ZH performed and analyzed the literature; Wen J performed the database search; Rao ZZ applied for and obtained the funds for this research project; All authors reviewed the results and approved the final version of the manuscript. Wang J and Liu ZX have made crucial and indispensable contributions towards the completion of the project and thus qualified as the co-first authors of the paper. Wen J and Rao ZZ have played important and indispensable roles in the database search and manuscript preparation as the co-corresponding authors.
Supported by Science Project of Hunan Provincial Healthy Commission, No. 20230844.
Conflict-of-interest statement: The authors declare that they have no competing interests.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jie Wen, PhD, Associate Professor, Department of Pediatric Orthopedics, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, No. 61 West Jiefang Road, Changsha 410013, Hunan Province, China. cashwj@qq.com
Received: December 9, 2024 Revised: February 2, 2025 Accepted: February 25, 2025 Published online: April 24, 2025 Processing time: 107 Days and 22.4 Hours
Abstract
Hepatocellular carcinoma (HCC) is the predominant form of primary liver cancer, accounting for 90% of all cases. Currently, early diagnosis of HCC can be achieved through serum alpha-fetoprotein detection, B-ultrasound, and computed tomography scanning; however, their specificity and sensitivity are suboptimal. Despite significant advancements in HCC biomarker detection, the prognosis for patients with HCC remains unfavorable due to tumor heterogeneity and limited understanding of its pathogenesis. Therefore, it is crucial to explore more sensitive HCC biomarkers for improved diagnosis, monitoring, and management of the disease. Long non-coding RNA (lncRNA) serves as an auxiliary carrier of genetic information and also plays diverse intricate regulatory roles that greatly contribute to genome complexity. Moreover, investigating gene expression regulation networks from the perspective of lncRNA may provide insights into the diagnosis and prognosis of HCC. We searched the PubMed database for literature, comprehensively classified regulated cell death mechanisms and systematically reviewed research progress on lncRNA-mediated cell death pathways in HCC cells. Furthermore, we prospectively summarize its potential implications in diagnosing and treating HCC.
Core Tip: The molecular mechanisms underlying hepatocellular carcinoma (HCC) development remain challenging to fully elucidate. The advent of high-throughput sequencing technologies has revealed that long non-coding RNAs (lncRNAs) play a pivotal role in gene regulation, contributing to cell proliferation, inhibiting apoptosis, promoting invasion and metastasis, and modulating metabolic processes. Dysregulation of lncRNAs is intricately linked to the progression of HCC, indicating their potential as prognostic markers and therapeutic targets. In this review, we systematically examine the research progress on lncRNA-mediated regulation of HCC cell death and discuss its potential therapeutic applications.
