Characteristics and distinct prognostic determinants of individuals with hepatosplenic T-cell lymphoma over the past two decades

Table 1 Demographic and Clinicopathologic characteristics of United States patients with hepatosplenic T-cell lymphoma between 2000 and 2017

Characteristics	n	%
Total	186	100
Gender
Female	58	31.18
Male	128	68.82
Age at diagnosis, yr
0-39	63	33.87
40-59	67	36.02
60-79	44	23.66
80+	12	6.45
Race
Non-Hispanic white	113	60.75
Non-Hispanic black	39	20.97
Hispanic	15	8.06
Other	19	10.22
Tumor stage
Localized	44	23.66
Regional	13	6.99
Distant	129	69.35
Living area
Counties in metropolitan areas of 1 million persons	118	63.44
Counties in metropolitan areas of 250000 to 1 million persons	38	20.43
Counties in metropolitan areas of 250000 persons	17	9.14
Nonmetropolitan counties	13	6.99
Income per year
$ < $55000	22	11.83
$55000-64999	33	17.74
$65000-74999	45	24.19
$75000+	86	46.24
Marital status
Married	82	44.09
Single/unknown	78	41.94
Divorced/separated	14	7.53
Widowed	12	6.45
Radiation
No	173	93.01
Yes	13	6.99
Surgery
No	116	62.37
Yes	70	37.63
B symptoms
No	122	65.59
Yes	64	34.41
Year of diagnosis
2000	1	0.54
2001	6	3.23
2002	5	2.69
2003	11	5.91
2004	10	5.38
2005	5	2.69
2006	11	5.91
2007	7	3.76
2008	8	4.30
2009	12	6.45
2010	11	5.91
2011	14	7.53
2012	10	5.38
2013	16	8.60
2014	12	6.45
2015	14	7.53
2016	14	7.53
2017	19	10.22

Table 2 Crude analysis of factors associated with all-cause mortality and hepatosplenic T-cell lymphoma mortality among patients between 2000 and 2017

Characteristics	Overall mortality crude proportional hazard ratio (95% confidence interval)	HSTCL crude proportional hazard ratio (95% confidence interval)
Gender
Female	1 (reference)	1 (reference)
Male	0.96 (0.65-1.39)	0.99 (0.65-1.52)
Age at diagnosis, yr
0-39	1 (reference)	1 (reference)
40-59	0.80 (0.53-1.22)	0.69 (0.44-1.11)
60-79	0.95 (0.59-1.54)	0.85 (0.50-1.45)
80+	1.60 (0.68-3.77)	1.44 (0.57-3.65)
Race
Non-Hispanic white	1 (reference)	1 (reference)
Non-Hispanic black	1.97 (1.27-3.07)b	2.34 (1.47-3.72)b
Hispanic	1.44 (0.71-2.89)	1.41 (0.64-3.13)
Other	1.65 (0.96-2.86)	1.62 (0.86-3.04)
Tumor stage
Localized	1 (reference)	1 (reference)
Regional	1.28 (0.57-2.86)	1.63 (0.62-4.30)
Distant	1.54 (0.97-2.43)	2.23 (1.24-4.02)b
Living area
Counties in metropolitan areas of 1 million persons	1 (reference)	1 (reference)
Counties in metropolitan areas of 250000 to 1 million persons	0.73 (0.46-1.16)	0.69 (0.41-1.17)
Counties in metropolitan areas of 250000 persons	1.19 (0.63-2.24)	1.02 (0.49-2.12)
Nonmetropolitan counties	1.43 (0.76-2.70)	1.22 (0.59-2.56)
Income per year
$ < $55000	1 (reference)	1 (reference)
$55000-64999	1.26 (0.65-2.45)	1.39 (0.65-2.99)
$65000-74999	1.18 (0.63-2.20)	1.25 (0.59-2.61)
$75000+	0.82 (0.45-1.49)	1.02 (0.51-2.03)
Marital status
Married	1 (reference)	1 (reference)
Single/unknown	1.12 (0.76-1.64)	1.32 (0.86-2.04)
Divorced/separated	1.49 (0.8-2.85)	1.77 (0.88-3.56)
Widowed	1.98 (0.89-4.38)	1.82 (0.72-4.65)
Radiation
No	1 (reference)	1 (reference)
Yes	0.77 (0.37-1.58)	0.81 (0.38-1.75)
Surgery
No	1 (reference)	1 (reference)
Yes	0.76 (0.53-1.09)	0.72 (0.48-1.09)
B symptoms
No	1 (reference)	1 (reference)
Yes	1.23 (0.85-1.80)	1.14 (0.75-1.75)

^bP < 0.01.

HSTCL: Hepatosplenic T-cell lymphoma.

Table 3 Multivariate cox proportional hazard regression analyses of factors affecting all-cause mortality and hepatosplenic T-cell lymphoma related mortality among patients between 2000 and 2017

Characteristics	Overall mortality adjusted proportional hazard ratio (95% confidence interval)	HSTCL adjusted proportional hazard ratio (95% confidence interval)
Gender
Female	1 (reference)	1 (reference)
Male	0.79 (0.48-1.29)	0.83 (0.49-1.41)
Age at diagnosis, yr
0-39	1 (reference)	1 (reference)
40-59	0.60 (0.32-1.13)	0.62 (0.30-1.26)
60-79	1.32 (0.67-2.58)	1.65 (0.78-3.49)
80+	2.98 (0.88-10.09)	4.72 (1.14-19.54)a
Race
Non-Hispanic white	1 (reference)	1 (reference)
Non-Hispanic black	1.61 (0.89-2.89)	2.02 (1.08-3.79)a
Hispanic	1.87 (0.73-4.78)	1.90 (0.69-5.28)
Other	1.59 (0.79-3.19)	1.49 (0.67-3.37)
Tumor stage
Localized	1 (reference)	1 (reference)
Regional	0.69 (0.24-2.01)	1.17 (0.33-4.19)
Distant	1.03 (0.57-1.87)	1.85 (0.87-3.89)
Living area
Counties in metropolitan areas of 1 million persons	1 (reference)	1 (reference)
Counties in metropolitan areas of 250,000 to 1 million persons	1.19 (0.69-2.07)	1.05 (0.55-2.02)
Counties in metropolitan areas of 250000 persons	1.07 (0.44-2.60)	0.68 (0.24-1.94)
Nonmetropolitan counties	2.71 (0.78-9.39)	2.36 (0.50-11.09)
Income per year
$ < $55000	1 (reference)	1 (reference)
$55000-64999	2.72 (0.82-9.07)	2.54 (0.58-11.08)
$65000-74999	1.75 (0.53-5.85)	1.04 (0.23-4.63)
$75000+	1.46 (0.43-4.96)	1.23 (0.28-5.53)
Marital status
Married	1 (reference)	1 (reference)
Single/unknown	0.83 (0.48-1.44)	0.94 (0.51-1.75)
Divorced/separated	1.33 (0.61-2.90)	1.79 (0.77-4.19)
Widowed	1.19 (0.39-3.62)	1.01 (0.26-3.87)
Radiation
No	1 (reference)	1 (reference)
Yes	0.86 (0.35-2.10)	1.07 (0.38-3.01)
Surgery
No	1 (reference)	1 (reference)
Yes	0.83 (0.49-1.40)	0.97 (0.54-1.76)
B symptoms
No	1 (reference)	1 (reference)
Yes	1.66 (0.85-3.24)	2.21 (0.99-4.89)

^aP < 0.05.

HSTCL: Hepatosplenic T-cell lymphoma.