Retrospective Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Jun 24, 2024; 15(6): 745-754
Published online Jun 24, 2024. doi: 10.5306/wjco.v15.i6.745
Characteristics and distinct prognostic determinants of individuals with hepatosplenic T-cell lymphoma over the past two decades
Ayrton Bangolo, Pierre Fwelo, Shraboni Dey, Tanni Sethi, Sowmya Sagireddy, Jawaria Chatta, Ashish Goel, Sneha Nagpaul, Eric Pin-Shiuan Chen, Chiranjeeve Saravanan, Sheeja Gangan, Joel Thomas, Sarah Potiguara, Vignesh K Nagesh, Daniel Elias, Charlene Mansour, Prajakta H Ratnaparkhi, Priyanshu Jain, Midhun Mathew, Taylor Porter, Shadiya Sultan, Shailaja Abbisetty, Linh Tran, Megha Chawla, Abraham Lo, Simcha Weissman, Christina Cho
Ayrton Bangolo, Shraboni Dey, Tanni Sethi, Jawaria Chatta, Ashish Goel, Sneha Nagpaul, Eric Pin-Shiuan Chen, Chiranjeeve Saravanan, Sheeja Gangan, Joel Thomas, Sarah Potiguara, Vignesh K Nagesh, Daniel Elias, Charlene Mansour, Prajakta H Ratnaparkhi, Priyanshu Jain, Midhun Mathew, Taylor Porter, Shadiya Sultan, Shailaja Abbisetty, Linh Tran, Megha Chawla, Simcha Weissman, Department of Internal Medicine, Palisades Medical Center, North Bergen, NJ 07047, United States
Pierre Fwelo, Department of Epidemiology, Human Genetics, and Environmental Sciences, UTHealth School of Public Health, Houston, TX 77030, United States
Sowmya Sagireddy, Abraham Lo, Department of Medicine, Palisades Medical Center, North Bergen, NJ 07047, United States
Christina Cho, Stem Cell Transplantation and Cellular Therapy, John Theurer Cancer Center, Hackensack, NJ 07601, United States
Author contributions: Bangolo A designed research; Bangolo A, Fwelo P performed research; Bangolo A, Fwelo P, Lo A, Weissman S, Cho C analyzed data; Bangolo A, Fwelo P, Dey S, Sethi T, Sagireddy S, Chatta J, Goel A, Nagpaul S, Chen EPS, Saravanan C, Gangan S, Thomas J, Potiguara S, Nagesh VK, Elias D, Mansour C, Ratnaparkhi PH, Jain P, Mathew M, Porter T, Shadiya Sultan, Abbisetty S, Tran L, Chawla M, Lo A, Weissman S, Cho C wrote the paper.
Institutional review board statement: The SEER Dataset was a public-use dataset, of which the need for IRB approval was waived.
Informed consent statement: The SEER Dataset was a public-use dataset, of which the informed consent was waived.
Conflict-of-interest statement: No potential conflict of interest was reported by the authors.
Data sharing statement: The data used and/or analyzed in this study are available in the Surveillance, Epidemiology, and End Results (SEER) Database of the National Cancer Institute (http://seer.cancer.gov).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ayrton Bangolo, Doctor, MBBS, MD, Doctor, Department of Internal Medicine, Palisades Medical Center, 7600 River Road, North Bergen, NJ 07047, United States. ayrtonbangolo0@gmail.com
Received: February 23, 2024
Revised: May 1, 2024
Accepted: May 21, 2024
Published online: June 24, 2024
Processing time: 121 Days and 20.7 Hours
Core Tip

Core Tip: Hepatosplenic T-cell lymphoma (HSTCL) is an uncommon and highly aggressive form of non-Hodgkin lymphoma that carries a very poor prognosis. Very little is known about the survival outcomes of patients with HSTCL given its rarity. This study will be the most updated and largest study on the survival outcomes of patients with HSTCL. We found that older age and Non-Hispanic black ethnicity are the single most important factors for poor prognosis.