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World J Clin Oncol. Aug 10, 2014; 5(3): 495-502
Published online Aug 10, 2014. doi: 10.5306/wjco.v5.i3.495
Pattern response of dendritic cells in the tumor microenvironment and breast cancer
Alessandra da Cunha, Marcia A Michelin, Eddie FC Murta
Alessandra da Cunha, Marcia A Michelin, Eddie FC Murta, Research Oncology Institute (IPON), Federal University of the Triângulo Mineiro (UFTM), Uberaba, Minas Gerais 38025-440, Brazil
Alessandra da Cunha, Marcia A Michelin, Eddie FC Murta, Discipline of Gynecology, Obstetric and Discipline of Immunology, Uberaba, Minas Gerais 38025-440, Brazil
Author contributions: All authors had idealized and designed the manuscript together; Cunha A had conducted the literature review on the issue and written the manuscript; Michelin MA and Murta EFC had organized the arrangement of ideas in the written material and oriented the manuscript final correction.
Supported by FAPEMIG and CNPq
Correspondence to: Eddie FC Murta, MD, PhD, Research Oncology Institute (IPON), Federal University of the Triângulo Mineiro (UFTM), Av. Getulio Guarita, sn Bairro Abadia, Uberaba, Minas Gerais 38025-440, Brazil. eddiemurta@mednet.com.br
Telephone: +55-34-33185326 Fax: +55-34-33185342
Received: December 29, 2013
Revised: March 7, 2014
Accepted: May 29, 2014
Published online: August 10, 2014
Processing time: 215 Days and 8.9 Hours
Core Tip

Core tip: Breast cancer is a worldwide major public health problem, and dendritic cells are of crucial importance for activating an effective antitumor immune response. Deepening our understanding of the tumor microenvironment can enable the development of new therapies that will make it possible to induce an efficacious antitumor response. Given the search for effective means with which to induce such a response via dendritic cell (DC) immunotherapy, the study of the mechanisms involved in the DC pattern of response in the tumor microenvironment is important.