Poly (ADP-ribose): A double-edged sword governing cancer cell survival and death

doi:10.5306/wjco.v15.i7.806

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Oncol. Jul 24, 2024; 15(7): 806-810
Published online Jul 24, 2024. doi: 10.5306/wjco.v15.i7.806

Poly (ADP-ribose): A double-edged sword governing cancer cell survival and death

Keun-Yeong Jeong, Ji-Hyuk Kang

Keun-Yeong Jeong, Head Office, Research Center, Seoul 07292, South Korea

Ji-Hyuk Kang, Department of Biomedical Laboratory Science, College of Health and Medical Science, Daejeon University, Daejeon 34520, South Korea

Author contributions: Jeong KY designed the overall concept and outline of the manuscript; Jeong KY conceived the contents and drafted the manuscript and contributed to the discussion; Jeong KY and Kang JH contributed to editing the manuscript, illustrations, and review of the literature; All authors have read and approved the final manuscript.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/licenses/by-nc/4.0/

Corresponding author: Keun-Yeong Jeong, PhD, Chief Technician, Founder and CEO, Head Office, Research Center, PearlsInMires, 150, Yeongdeungpo-ro, Yeongdeungpo-gu, Seoul 07292, South Korea. alvirus@naver.com

Received: March 30, 2024
Revised: June 10, 2024
Accepted: June 28, 2024
Published online: July 24, 2024
Processing time: 107 Days and 23.7 Hours

Core Tip

Core Tip: The biosynthesis of Poly (ADP-ribose) (PAR) by PAR polymerase plays a pivotal role in modulating cellular processes that dictate the survival or death of cancer cells. Considering the dichotomous functions of PAR is instrumental in unveiling novel strategies for cancer treatment.