Jeong KY, Kang JH. Poly (ADP-ribose): A double-edged sword governing cancer cell survival and death. World J Clin Oncol 2024; 15(7): 806-810 [PMID: 39071462 DOI: 10.5306/wjco.v15.i7.806]
Corresponding Author of This Article
Keun-Yeong Jeong, PhD, Chief Technician, Founder and CEO, Head Office, Research Center, PearlsInMires, 150, Yeongdeungpo-ro, Yeongdeungpo-gu, Seoul 07292, South Korea. alvirus@naver.com
Research Domain of This Article
Oncology
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Oncol. Jul 24, 2024; 15(7): 806-810 Published online Jul 24, 2024. doi: 10.5306/wjco.v15.i7.806
Poly (ADP-ribose): A double-edged sword governing cancer cell survival and death
Keun-Yeong Jeong, Ji-Hyuk Kang
Keun-Yeong Jeong, Head Office, Research Center, Seoul 07292, South Korea
Ji-Hyuk Kang, Department of Biomedical Laboratory Science, College of Health and Medical Science, Daejeon University, Daejeon 34520, South Korea
Author contributions: Jeong KY designed the overall concept and outline of the manuscript; Jeong KY conceived the contents and drafted the manuscript and contributed to the discussion; Jeong KY and Kang JH contributed to editing the manuscript, illustrations, and review of the literature; All authors have read and approved the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Keun-Yeong Jeong, PhD, Chief Technician, Founder and CEO, Head Office, Research Center, PearlsInMires, 150, Yeongdeungpo-ro, Yeongdeungpo-gu, Seoul 07292, South Korea. alvirus@naver.com
Received: March 30, 2024 Revised: June 10, 2024 Accepted: June 28, 2024 Published online: July 24, 2024 Processing time: 107 Days and 23.7 Hours
Abstract
Poly (ADP-ribose) (PAR), a polymer of ADP-ribose, is synthesized by PAR polymerase and is crucial for the survival of cancer cells due to its vital functions in DNA repair and post-translational modifications. Beyond its supportive role, PAR also triggers cancer cell death by excessive accumulation of PAR leading to an energy crisis and parthanatos. This phenomenon underscores the potential of targeting PAR regulation as a novel anticancer strategy, and the rationale would present an engaging topic in the field of anticancer research. Therefore, this editorial provides an overview of the mechanisms determining cancer cell fate, emphasizing the central role of PAR. It further introduces promising methods for modulating PAR concentrations that may pave the way for innovative anticancer therapies.
Core Tip: The biosynthesis of Poly (ADP-ribose) (PAR) by PAR polymerase plays a pivotal role in modulating cellular processes that dictate the survival or death of cancer cells. Considering the dichotomous functions of PAR is instrumental in unveiling novel strategies for cancer treatment.
