Zhang PS, Wang R, Wu HW, Zhou H, Deng HB, Fan WX, Li JC, Cheng SW. Non-Hodgkin's lymphoma involving chronic difficult-to-heal wounds: A case report. World J Clin Oncol 2024; 15(8): 1110-1116 [PMID: 39193160 DOI: 10.5306/wjco.v15.i8.1110]
Corresponding Author of This Article
Shao-Wen Cheng, PhD, Associate Chief Physician, Department of Wound Repair, Key Laboratory of Emergency and Trauma of Ministry of Education, The First Affiliated Hospital of Hainan Medical University, No. 31 Longhua Road, Haikou 570102, Hainan Province, China. chengshaowen1@126.com
Research Domain of This Article
Emergency Medicine
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Oncol. Aug 24, 2024; 15(8): 1110-1116 Published online Aug 24, 2024. doi: 10.5306/wjco.v15.i8.1110
Non-Hodgkin's lymphoma involving chronic difficult-to-heal wounds: A case report
Pei-Shen Zhang, Rong Wang, Hu-Wen Wu, Han Zhou, Han-Bin Deng, Wen-Xuan Fan, Jia-Cheng Li, Shao-Wen Cheng
Pei-Shen Zhang, Rong Wang, Hu-Wen Wu, Han Zhou, Han-Bin Deng, Wen-Xuan Fan, Jia-Cheng Li, Shao-Wen Cheng, Department of Wound Repair, Key Laboratory of Emergency and Trauma of Ministry of Education, The First Affiliated Hospital of Hainan Medical University, Haikou 570102, Hainan Province, China
Co-first authors: Pei-Shen Zhang and Rong Wang.
Author contributions: Zhang PS and Wang Y contributed to manuscript writing and editing, and data collection; Wu HW, Zhou H, Deng HB, Fan WX, and Li JC contributed to data analysis; Cheng SW contributed to conceptualization and supervision; all authors have read and approved the final manuscript.
Supported byNatural Science Foundation of Hainan Province, China, No. 822MS174.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: All authors declare that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Shao-Wen Cheng, PhD, Associate Chief Physician, Department of Wound Repair, Key Laboratory of Emergency and Trauma of Ministry of Education, The First Affiliated Hospital of Hainan Medical University, No. 31 Longhua Road, Haikou 570102, Hainan Province, China. chengshaowen1@126.com
Received: May 15, 2024 Revised: July 10, 2024 Accepted: July 16, 2024 Published online: August 24, 2024 Processing time: 92 Days and 15 Hours
Abstract
BACKGROUND
Non-Hodgkin's lymphoma (NHL) is a malignant tumor that originates from the lymphoid tissues and can potentially affect numerous organs within the body. Among these, the skin stands out as one of the primary sites affected by NHL, often presenting with multiple extra-nodal manifestations. In this report, we present an unusual case of NHL involving chronic wounds in the lower extremities that were difficult to heal. The scars were successfully treated using radiotherapy in combination with extended excision debridement and peroneal artery perforator flap grafting, resulting in satisfactory outcomes.
CASE SUMMARY
A 19-year-old male patient presented with ulceration of the skin on the left calf near the ankle accompanied by purulent discharge. Subsequent pathologic biopsy confirmed a diagnosis of NHL (extranodal NK/T-cell lymphoma, nasal type). Initial treatment comprised local radiotherapy and wound care; however, the wound exhibited prolonged non-healing. Consequently, the patient underwent a series of interventions including radiotherapy, wound enlargement excision debridement, and peroneal artery perforator flap grafting. Ultimately, successful healing was achieved with favorable postoperative outcomes characterized by good texture of the flap without any signs of rupture or infection.
CONCLUSION
The combination of radiotherapy, wound enlargement excision debridement, and peroneal artery perforator flap grafting may present a favorable treatment modality for chronic non-healing lower leg wounds resulting from NHL.
Core Tip: Non-Hodgkin's lymphoma represents the majority of lymphoma cases, and extranodal natural killer/T-cell lymphoma, a rare subtype, is characterized by its rarity, high aggressiveness, and poor prognosis. Skin lesions typically present as nodules and hard lumps, with wounds in the lower limbs being relatively uncommon. Here we present the case of a 19-year-old male diagnosed with non-Hodgkin's lymphoma due to an 11-month history of chronic skin breakdown with effusion on the left lower leg near the ankle. Conventional radiotherapy and wound care resulted in poor wound healing. However, after undergoing radiotherapy followed by wound enlargement excision debridement combined with peroneal artery perforator flap grafting, the wound healed successfully.
