Thiol/disulphide homeostasis in celiac disease

doi:10.4292/wjgpt.v8.i2.120

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 8, Issue 2

This Article

Academic Content and Language Evaluation of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (10389)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Tables (1-3) series.

Item

Count

PDF

700

WORD

323

HTML

4064

Tables (1-3)

296

Sum=5383

Featured Article

The chart showing Browse series, Download series.

Item

Count

Browse

829

Download

1331

Sum=2160

Publishing Process of This Article

Item

Count

Browse

1136

Download

1710

Sum=2846

May 6, 2017 (publication date) through Jan 20, 2025

Times Cited of This Article

Times Cited (17)

Journal Information of This Article

Publication Name

World Journal of Gastrointestinal Pharmacology and Therapeutics

ISSN

2150-5349

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Case Control Study

World J Gastrointest Pharmacol Ther. May 6, 2017; 8(2): 120-126
Published online May 6, 2017. doi: 10.4292/wjgpt.v8.i2.120

Table 1 Demographic characteristics and laboratory findings of study population

Variables	Celiac (n = 73)	Control (n = 73)	P value
Gender (male), n (%)	15 (20.5)	18 (24.7)	0.553
Age (yr)	44.1 ± 13	43.7 ± 13.6	0.866
BMI (kg/m²)	24.5 ± 4.7	24.9 ± 4.7	0.867
Smoking, n (%)
Non-smokers	49 (67.1)	50 (68.5)
Smokers	18 (24.7)	17 (23.3)	0.981
Quit smoking	6 (8.2)	6 (8.2)
Alcohol, n (%)	2 (2.7)	-	-
Duration of disease (yr)	6 (1-25)	-	-
Total protein (g/L)	7.4 ± 0.6	7.4 ± 0.5	0.964
Albumin (g/L)	4.4 ± 0.3	4.1 ± 0.3	0.002^a
ALT (IU/L)	23 (8)	20 (7)	0.035^a
AST (IU/L)	20 (12)	17 (9)	0.002^a
CRP (mg/L)	3.5 (8.4)	1.2 (2)	0.008^a
Native thiol (μmol/L)	322.7 ± 39.7	339.6 ± 51.3	0.027^a
Total thiol (μmol/L)	343.7 ± 41.9	360.4 ± 50.3	0.031^a
Disulphide (μmol/L)	13.0 ± 3.7	10.2 ± 3.9	< 0.001^a
Disulphide/native thiol (%)	3.8 ± 1.2	2.8 ± 1.1	< 0.001^a
Disulphide/total thiol (%)	4.1 ± 1.4	2.9 ± 1.1	< 0.001^a
Native thiol/total thiol (%)	93.8 ± 2.6	94.3 ± 5.7	0.553

^aP < 0.05. BMI: Body mass index; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; CRP: C-reactive protein.

Table 2 Dietary compliance of native thiol, disulphide and disulphide/native thiol and its distribution regarding antibody positivity

Variables	Native thiol (μmol/L)	P value	Disulphide (μmol/L)	P value	Disulphide/native thiol (μmol/L)	P value
Diet
GCD (n = 22)	310.6 ± 46.8	0.013^a	13.8 ± 3.2	0.034^a	5.2 ± 1.4	< 0.001^a
GFD (n = 51)	327.9 ± 35.6		12.0 ± 3.3		3.5 ± 1.7
AGA-IgA
(-) (n = 33)	310.5 ± 39.5	0.015^a	14.1 ± 3.7	0.020^a	4.7 ± 1.9	0.005^a
(+) (n = 40)	333.8 ± 40.1		12.0 ± 3.8		3.6 ± 1.4
AGA-IgG
(-) (n = 47)	308.5 ± 36.8	0.027^a	13.9 ± 3.1	0.001^a	4.6 ± 1.7	< 0.001^a
(+) (n = 26)	330.5 ± 45.2		11.1 ± 3.9		3.0 ± 1.1
Anti-t TGA
(-) (n = 29)	315.5 ± 38.2	0.001^a	13.9 ± 3.9	0.019^a	4.5 ± 1.9	0.007^a
(+) (n = 44)	346.2 ± 40.5		11.7 ± 3.8		3.4 ± 1.5
Anti-t TGG
(-) (n = 61)	318.1 ± 37.6	0.002^a	13.5 ± 3.9	0.009^a		0.035^a
(+) (n = 12)	345.3 ± 51.5		10.3 ± 3.0

^aP < 0.05. GCD: Gluten-containing diet; GFD: Gluten-free diet; AGA-IgA: Anti gliadin antibodies IgA; AGA-IgG: Anti gliadin antibodies IgG; Anti-t TGA: Anti-tissue Transglutaminase IgA antibodies; Anti-t TGG: Anti-tissue Transglutaminase IgA antibodies.

Table 3 Findings related to thiol/disulphide hemostasis parameters in celiac patient group

Variables	Native thiol		Total thiol		Disulphide		Disulphide/total thiol		Disulphide/native thiol		Native thiol/total thiol
Variables	r	P value	r	P value	r	P value	r	P value	r	P value	r	P value
Age	0.261	0.026^a	0.262	0.025^a	-0.041	0.729	-0.132	0.264	-0.122	0.302	0.021	0.861
BMI	0.19	0.107	0.187	0.114	-0.033	0.783	-0.096	0.421	-0.113	0.34	0.045	0.702
Total protein	-0.032	0.786	0.005	0.97	0.059	0.618	0.032	0.787	0.086	0.472	-0.156	0.187
Albumin	0.009	0.937	0.025	0.835	-0.037	0.754	-0.065	0.582	-0.040	0.735	-0.071	0.548
AST	0.051	0.666	0.046	0.702	-0.03	0.801	-0.057	0.631	-0.031	0.796	0.033	0.781
ALT	-0.091	0.444	-0.116	0.329	-0.063	0.598	-0.012	0.919	0.002	0.985	0.094	0.427
CRP	-0.327	0.018^a	-0.304	0.038^a	0.369	0.015^a	0.287	0.043^a	0.332	0.029^a	-0.244	0.038^a
AGA-IgA	-0.325	0.009^a	-0.266	0.035^a	0.384	0.024^a	0.324	0.010^a	0.325	0.009^a	-0.266	0.035^a
AGA-IgG	-0.332	0.008^a	-0.271	0.022^a	0.298	0.010^a	0.297	0.011^a	0.253	0.031^a	-0.279	0.017^a
Anti-t TGA	-0.342	0.007^a	-0.28	0.017^a	0.305	0.009^a	0.311	0.004^a	0.280	0.035^a	-0.294	0.028^a
Anti-t TGG	-0.35	0.00^a	-0.316	0.004^a	0.315	0.007^a	0.34	0.001^a	0.302	0.014^a	-0.304	0.019^a
AGA-IgA¹	-0.313	0.006^a	-0.301	0.026^a	0.334	0.004^a	0.353	< 0.001^a	0.315	0.011^a	-0.319	0.013^a
AGA-IgG¹	-0.335	0.004^a	-0.324	0.005^a	0.309	0.018^a	0.366	0.023^a	0.349	0.033^a	-0.288	0.045^a
Anti-t TGA¹	-0.261	0.043^a	-0.243	0.035^a	0.376	0.036^a	0.322	0.011^a	0.335	0.009^a	-0.273	0.038^a
Anti-t TGG¹	-0.333	0.032^a	-0.282	0.037^a	0.294	0.031^a	0.305	0.026^a	0.336	0.036^a	-0.314	0.013^a

^aP < 0.05.

¹Demographic characteristics and laboratory parameters are adjusted. BMI: Body mass index; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; CRP: C-reactive protein; AGA-IgA: Anti gliadin antibodies IgA; AGA-IgG: Anti gliadin antibodies IgG; Anti-t TGA: Anti-tissue Transglutaminase IgA antibodies; Anti-t TGG: Anti-tissue Transglutaminase IgA antibodies.

Citation: Kaplan M, Ates I, Yuksel M, Ozderin Ozin Y, Alisik M, Erel O, Kayacetin E. Thiol/disulphide homeostasis in celiac disease. World J Gastrointest Pharmacol Ther 2017; 8(2): 120-126
URL: https://www.wjgnet.com/2150-5349/full/v8/i2/120.htm
DOI: https://dx.doi.org/10.4292/wjgpt.v8.i2.120