Case Control Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Pharmacol Ther. May 6, 2017; 8(2): 120-126
Published online May 6, 2017. doi: 10.4292/wjgpt.v8.i2.120
Thiol/disulphide homeostasis in celiac disease
Mustafa Kaplan, Ihsan Ates, Mahmut Yuksel, Yasemin Ozderin Ozin, Murat Alisik, Ozcan Erel, Ertugrul Kayacetin
Mustafa Kaplan, Mahmut Yuksel, Yasemin Ozderin Ozin, Ertugrul Kayacetin, Department of Gastroenterology, Turkey Yuksek Ihtisas Training and Research Hospital, 06500 Ankara, Turkey
Ihsan Ates, Department of Internal Medicine, Ankara Numune Training and Research Hospital, 06500 Ankara, Turkey
Murat Alisik, Ozcan Erel, Department of Biochemistry, Yıldırım Beyazıt University Medical Faculty, 06500 Ankara, Turkey
Author contributions: Kaplan M and Ates I contributed equally to this work; Kaplan M, Ates I and Yuksel M collected and analyzed the data, and drafted the manuscript; Alisik M and Erel O provided analytical oversight; Ozderin Ozin Y and Kayacetin E designed and supervised the study; Kaplan M, Ates I, Alisik M and Erel O revised the manuscript for important intellectual content; Ozderin Ozin Y and Kaycetin E offered the technical or material support; Kaplan M and Ates I provided administrative support; all authors have read and approved the final version to be published.
Institutional review board statement: The study was designed around the 2013 Brazil version of the Declaration of Helsinki. It was approved by the Turkey Yuksek Ihtisas Training and Research Hospital Ethical Board Research Commission.
Informed consent statement: Written consent was taken from all participants who were included in the study.
Conflict-of-interest statement: The authors declared that there is no conflict of interest.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at dr.ihsanates@hotmail.com. No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Ihsan Ates, MD, Department of Internal Medicine, Ankara Numune Training and Research Hospital, 06500 Ankara, Turkey. dr.ihsanates@hotmail.com
Telephone: +90-312-5084675 Fax: +90-312-3569003
Received: November 30, 2016
Peer-review started: December 2, 2016
First decision: January 5, 2017
Revised: January 25, 2017
Accepted: March 12, 2017
Article in press: March 14, 2017
Published online: May 6, 2017
Processing time: 154 Days and 10.4 Hours
Core Tip

Core tip: To the best of our knowledge, for the first time in this study, total and native thiol levels in celiac patients were found lower compared to the control group while disulphide level, disulphide/total thiol and disulphide/native thiol ratios were found to be higher. Also, this study is first in which a negative correlation between celiac autoantibodies and native thiol, and total thiol levels and native thiol/total thiol ratio is observed while there is a positive correlation between disulphide level and disulphide/native thiol and disulphide/total thiol ratios.