Kumar H, Fernandez CJ, Kolpattil S, Munavvar M, Pappachan JM. Discrepancies in the clinical and radiological profiles of COVID-19: A case-based discussion and review of literature. World J Radiol 2021; 13(4): 75-93 [PMID: 33968311 DOI: 10.4329/wjr.v13.i4.75]
Corresponding Author of This Article
Joseph M Pappachan, MD, FRCP, Consultant Physician-Scientist, Honorary Professor, Senior Researcher, Department of Medicine & Endocrinology, Lancashire Teaching Hospitals NHS Trust, Sharoe Green Lane, Preston PR2 9HT, United Kingdom. drpappachan@yahoo.co.in
Research Domain of This Article
Radiology, Nuclear Medicine & Medical Imaging
Article-Type of This Article
Evidence Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Radiol. Apr 28, 2021; 13(4): 75-93 Published online Apr 28, 2021. doi: 10.4329/wjr.v13.i4.75
Discrepancies in the clinical and radiological profiles of COVID-19: A case-based discussion and review of literature
Hemant Kumar, Cornelius James Fernandez, Sangeetha Kolpattil, Mohamed Munavvar, Joseph M Pappachan
Hemant Kumar, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TH, United Kingdom
Cornelius James Fernandez, Department of Medicine & Endocrinology, Pilgrim Hospital, Boston PE21 9QS, United Kingdom
Sangeetha Kolpattil, Department of Radiology, University Hospitals of Morecambe Bay NHS Trust, Lancaster LA1 4RP, United Kingdom
Mohamed Munavvar, Department of Pulmonology & Chest Diseases, Lancashire Teaching Hospitals NHS Trust, Preston PR2 9HT, United Kingdom
Joseph M Pappachan, Department of Medicine & Endocrinology, Lancashire Teaching Hospitals NHS Trust, Preston PR2 9HT, United Kingdom
Joseph M Pappachan, Faculty of Science, Manchester Metropolitan University, Manchester M15 6BH, United Kingdom
Joseph M Pappachan, Faculty of Biology, Medicine & Health, The University of Manchester, Manchester M13 9PL, United Kingdom
Author contributions: Kumar H and Fernandez CJ performed majority of the initial drafting, prepared the figures and tables, and share the first authorship of the paper; Kolpattil S and Munavvar M did additional literature search, and made critical revisions in the write up; Pappachan JM conceived the idea, made critical revisions, and provided final approval of the final version of the manuscript to be published.
Conflict-of-interest statement: Dr. Pappachan and coauthors have nothing to declare.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Joseph M Pappachan, MD, FRCP, Consultant Physician-Scientist, Honorary Professor, Senior Researcher, Department of Medicine & Endocrinology, Lancashire Teaching Hospitals NHS Trust, Sharoe Green Lane, Preston PR2 9HT, United Kingdom. drpappachan@yahoo.co.in
Received: December 16, 2020 Peer-review started: December 16, 2020 First decision: March 31, 2021 Revised: April 3, 2021 Accepted: April 13, 2021 Article in press: April 13, 2021 Published online: April 28, 2021
Core Tip
Core Tip: The coronavirus disease-19 (COVID-19) pandemic has had a devastating impact on the human race, with the current death toll exceeding 2.8 million. Although a positive reverse transcriptase polymerase chain reaction test is the gold standard for diagnosing a COVID-19 infection, the reported sensitivity of the test is < 90%, and clinicians often need to rely upon various imaging studies for definitive diagnoses and prognostication. However, discrepancies between the clinical and imaging profiles of patients with the disease can often pose challenges in therapeutic decision making. Therefore, it is imperative to understand the diagnostic sensitivity, specificity, and positive and negative predictive values of each imaging modality for the rational management of patients with this enigmatic disease. This evidence-based review is a clinical update to empower clinicians across the world who is involved in combatting COVID-19.
