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Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Cardiol. Feb 26, 2022; 14(2): 64-82
Published online Feb 26, 2022. doi: 10.4330/wjc.v14.i2.64
Exercise stress echocardiography: Where are we now?
Carlos Alberto Cotrim, Hugo Café, Isabel João, Nuno Cotrim, Jorge Guardado, Pedro Cordeiro, Hortense Cotrim, Luis Baquero
Carlos Alberto Cotrim, Luis Baquero, Heart Center, Hospital da Cruz Vermelha Portuguesa, Lisboa 1549-008, Portugal
Hugo Café, Hortense Cotrim, Faculdade de Medicina, Algarve University, Faro 8005-139, Portugal
Isabel João, Department of Cardiology, Garcia de Orta Hospital, Almada 2805-267, Portugal
Nuno Cotrim, Department of Medicine, Garcia de Orta Hospital, Almada 2805-267, Portugal
Jorge Guardado, Cardiovascular Unit, UCARDIO, Centro Clinico, Riachos 2350-325, Portugal
Pedro Cordeiro, Department of Cardiology, Hospital Particular do Algarve, Faro 8005-226, Portugal
Author contributions: Cotrim C reviewed the literature and wrote the paper; Café H, João I, Cotrim N, Guardado J, Cordeiro P, and Baquero L reviewed the literature and the paper for important intellectual content; and Cotrim H reviewed the literature related to bioethics and radiation use in cardiovascular disease investigation and treatment and wrote this part of the article.
Conflict-of-interest statement: The authors have no Conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Carlos Alberto Cotrim, MD, PhD, Professor, Heart Center, Hospital da Cruz Vermelha Portuguesa, Rua Duarte Galvão, 54, Lisboa 1549-008, Portugal. carlosadcotrim@gmail.com
Received: March 20, 2021
Peer-review started: March 20, 2021
First decision: June 17, 2021
Revised: July 4, 2021
Accepted: January 29, 2022
Article in press: January 29, 2022
Published online: February 26, 2022
Processing time: 333 Days and 3.2 Hours
Abstract

Exercise stress echocardiography (ESE) is a widely used diagnostic test in cardiology departments. ESE is mainly used to study patients with coronary artery disease; however, it has increasingly been used in other clinical scenarios including valve pathology, congenital heart disease, hypertrophic and dilated cardiomyopathies, athlete evaluations, diastolic function evaluation, and pulmonary circulation study. In our laboratories, we use an established methodology in which cardiac function is evaluated while exercising on a treadmill. After completing the exercise regimen, patients remain in a standing position or lie down on the left lateral decubitus, depending on the clinical questions to be answered for further evaluation. This method increases the quality and quantity of information obtained. Here, we present the various methods of exercise stress echocardiography and our experience in many clinical arenas in detail. We also present alternatives to ESE that may be used and their advantages and disadvantages. We review recent advances in ESE and future directions for this established method in the study of cardiac patients and underline the advantage of using a diagnostic tool that is radiation-free.

Keywords: Exercise stress echocardiography; Coronary artery disease; Valve disease; Athletes; Intraventricular gradients; Children

Core Tip: The fair cost, safety, diagnostic accuracy, ability to evaluate functional capacity, and lack of radiation use associated with exercise stress echocardiography (ESE) render this method a first-line procedure for patients with suspected or confirmed coronary heart disease. The evaluation of Doppler data and the enormous amount of information obtained during and after exercise, including in a standing position if appropriate, in patients with hypertrophic cardiomyopathy, athletes, syndrome X patients and patients with valve and congenital heart disease necessitates the use of ESE.