Sirizi MAG, Alizadeh Ghalenoei J, Allahtavakoli M, Forouzanfar H, Bagheri SM. Anticancer potential of Ferula assa-foetida and its constituents, a powerful plant for cancer therapy. World J Biol Chem 2023; 14(2): 28-39 [PMID: 37034135 DOI: 10.4331/wjbc.v14.i2.28]
Corresponding Author of This Article
Seyyed Majid Bagheri, PhD, Assistant Professor, Department of Physiology, Hematology-oncology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd 8915173149, Iran. seyyedmajidbagheri@gmail.com
Research Domain of This Article
Oncology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Biol Chem. Mar 27, 2023; 14(2): 28-39 Published online Mar 27, 2023. doi: 10.4331/wjbc.v14.i2.28
Anticancer potential of Ferula assa-foetida and its constituents, a powerful plant for cancer therapy
Mohammad Amin Ghaffari Sirizi, Jalil Alizadeh Ghalenoei, Mohammad Allahtavakoli, Hasan Forouzanfar, Seyyed Majid Bagheri
Mohammad Amin Ghaffari Sirizi, Jalil Alizadeh Ghalenoei, Seyyed Majid Bagheri, Department of Physiology, Hematology-oncology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd 8915173149, Iran
Mohammad Allahtavakoli, Department of Physiology and Pharmacology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan 8915173149, Iran
Hasan Forouzanfar, Department of Nursing, Tabas School of nursing, Birjand University of Medical Sciences, Birjand 8915173149, Iran
Author contributions: Bagheri SM and Allahtavakoli M designed the research study; Sirizi MAG and Alizadeh Ghalenoei J analyzed the data and wrote the manuscript; Forouzanfar H contributed new reagents and analytic tools; Bagheri SM Final review and editing; All authors have read and approve the final manuscript.
Conflict-of-interest statement: All the author declare no conflict of interests for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Seyyed Majid Bagheri, PhD, Assistant Professor, Department of Physiology, Hematology-oncology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd 8915173149, Iran. seyyedmajidbagheri@gmail.com
Received: November 10, 2022 Peer-review started: November 10, 2022 First decision: January 20, 2023 Revised: January 24, 2023 Accepted: February 21, 2023 Article in press: February 21, 2023 Published online: March 27, 2023
Abstract
Cancer is one of the main challenges of the health system around the world. This disease is increasing in developing countries and imposes heavy costs on patients and governments. On the other hand, despite various drugs, the death rate among cancer patients is still high and the current treatments have many harmful effects. In the traditional medicine of different countries, there are many medicinal plants that can be effective in the treatment of cancer. Ferula plants are traditionally used as spices and food or for medicinal purposes. Ferula assa-foetida is one of the famous plants of this genus, which has been used for the treatment of various diseases since ancient times. Among the main compounds of this plant, we can mention monoterpenes, sulfide compounds and polyphenols, which can show different therapeutic effects. This article has been compiled with the aim of collecting evidence and articles related to the anti-cancer effects of extracts, derived compounds, essential oils and nanoparticles containing Ferula assa-foetida. This review article was prepared by searching the terms Ferula assa-foetida and cancer, and relevant information was collected through searching electronic databases such as ISI Web of Knowledge, PubMed, and Google Scholar. Fortunately, the results of this review showed that relatively comprehensive studies have been conducted in this field and shown that Ferula assa-foetida can be very promising in the treatment of cancer.
Core Tip: Finding new anti-cancer compounds is an important necessity in the treatment or prevention of this disease. Ferula assa-foetida has useful compounds for the prevention and treatment of cancer, which can be used in making new compounds. These compounds include sulphide compounds, flavonoids and terpene coumarins, which with new methods such as making emulsions and nanoparticles from these compounds can be of great help in reducing the costs of cancer patients and their life expectancy.
