Diagnostic implications of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and systemic immune-inflammatory index for gastric carcinoma

Table 1 Analysis of clinical data of gastric carcinoma and precancerous gastric condition groups

Clinical data	Precancerous gastric condition (n = 134)	GC (n = 133)	χ2/t	P value
Gender, n (%)			9.504	0.002
Male	69 (51.49)	93 (69.92)
Female	65 (48.51)	40 (30.08)
Age (year)	61.76 ± 9.31	66.27 ± 10.54	3.706	< 0.001
BMI (kg/m2)	23.45 ± 3.01	22.26 ± 3.20	3.130	0.002
Neutrophil count	2.64 ± 0.78	3.44 ± 1.28	6.172	< 0.001
Lymphocyte count	1.88 ± 0.56	1.87 ± 0.55	0.147	0.883
Platelet count	199.46 ± 51.28	235.90 ± 76.38	4.580	< 0.001

GC: Gastric carcinoma; BMI: Body mass index.

Table 2 Variable assignment

Variable	Assignment method
Gender	Female = 0, male = 1
Age (year)	Continuous variable
BMI (kg/m2)	Continuous variable
Neutrophil count	Continuous variable
Lymphocyte count	Continuous variable
Platelet count	Continuous variable
NLR	Continuous variable
PLR	Continuous variable
SII	Continuous variable

NLR: Neutrophil-to-lymphocyte ratio; PLR: Platelet-to-lymphocyte ratio; SII: Systemic immune-inflammatory index; BMI: Body mass index.

Table 3 Analysis of risk factors affecting gastric carcinoma

Variable	β	SE	Wald	P value	Exp (β)	95%CI
Gender	0.974	0.365	7.111	0.008	2.649	1.295-5.420
Age (year)	0.033	0.017	3.755	0.053	1.034	1.000-1.069
BMI (kg/m2)	-0.145	0.063	5.325	0.021	0.865	0.765-0.978
Neutrophil count	-0.457	0.704	0.421	0.517	0.633	0.159-2.519
Lymphocyte count	0.718	0.400	3.213	0.073	2.049	0.935-4.491
Platelet count	-0.004	0.012	0.106	0.745	0.996	0.972-1.020
NLR	0.293	1.428	0.042	0.837	1.340	0.082-22.007
PLR	-0.002	0.016	0.012	0.911	0.998	0.968-1.030
SII	0.012	0.008	2.118	0.146	1.012	0.996-1.029

95%CI: 95% confidence interval; NLR: Neutrophil-to-lymphocyte ratio; PLR: Platelet-to-lymphocyte ratio; SII: Systemic immune-inflammatory index; BMI: Body mass index.

Table 4 Diagnostic implications of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and systemic immune-inflammatory index for gastric carcinoma

Indicators	AUC	SE	P value	Specificity (%)	Sensitivity (%)	Optimal cutoff
NLR	0.824	0.026	< 0.001	91.04	65.41	1.975
PLR	0.787	0.028	< 0.001	81.34	63.16	136.000
SII	0.842	0.025	< 0.001	82.84	74.44	372.700
Combined detection	0.848	0.024	< 0.001	81.34	76.69	0.433

AUC: Area under the curve; GC: Gastric carcinoma; NLR: Neutrophil-to-lymphocyte ratio; PLR: Platelet-to-lymphocyte ratio; SII: Systemic immune-inflammatory index.