Retrospective Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Jan 27, 2025; 17(1): 100130
Published online Jan 27, 2025. doi: 10.4240/wjgs.v17.i1.100130
Diagnostic implications of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and systemic immune-inflammatory index for gastric carcinoma
Huang-Min Wu, Xiao-Xuan Ying, Li-Li Lv, Jian-Wen Hu
Huang-Min Wu, Xiao-Xuan Ying, Li-Li Lv, Jian-Wen Hu, Department of Gastroenterology, Dongyang People's Hospital, Dongyang 322100, Zhejiang Province, China
Author contributions: Wu HM contributed to the manuscript writing, data collection and analysis; Wu HM and Ying XX collected data; Wu HM, Lv LL and Hu JW were involved in the conceptualization and supervision of this manuscript; all authors approved the final manuscript.
Institutional review board statement: This study was approved by the Ethic Committee of Dongyang People's Hospital.
Informed consent statement: The requirement for written informed consent was waived due to retrospective design of the study.
Conflict-of-interest statement: Dr. Wu has nothing to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Huang-Min Wu, MM, Attending Doctor, Department of Gastroenterology, Dongyang People's Hospital, No. 60 Wuning West Road, Dongyang 322100, Zhejiang Province, China. wuhuanming521@163.com
Received: August 20, 2024
Revised: September 19, 2024
Accepted: September 27, 2024
Published online: January 27, 2025
Processing time: 129 Days and 4.4 Hours
Abstract
BACKGROUND

The diagnosis of gastric carcinoma (GC) is essential for improving clinical outcomes. However, the biomarkers currently used for GC screening are not ideal.

AIM

To explore the diagnostic implications of the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammatory index (SII) for GC.

METHODS

The baseline data of 133 patients with GC and 134 patients with precancerous gastric conditions admitted between January 2022 and December 2023 were retrospectively analyzed. The information on peripheral blood platelet, neutrophil, and lymphocyte counts in each patient was collected, and the NLR, PLR, and SII levels of both groups were calculated. Additionally, multivariate logistic regression analysis was conducted, and the diagnostic implications of NLR, PLR, and SII in differentiating patients with precancerous gastric conditions, compared with those with GC, were analyzed through receiver operating characteristic (ROC) curves.

RESULTS

The data indicated that NLR, PLR, and SII had abnormally increased levels in the patients with GC. Gender and body mass index were risk factors for the occurrence of GC. ROC data revealed that the areas under the curve of three patients with precancerous gastric conditions, who were differentiated from those with GC, were 0.824, 0.787, and 0.842, respectively.

CONCLUSION

NLR, PLR, and SII are all abnormally expressed in GC and have diagnostic implications, especially when used as joint indicators, in distinguishing patients with precancerous gastric conditions from those with GC.

Keywords: Gastric carcinoma; Neutrophil-to-lymphocyte ratio; Platelet-to-lymphocyte ratio; Precancerous gastric conditions; Systemic immune-inflammatory index

Core Tip: This study included 133 patients with gastric carcinoma (GC) and 134 with precancerous gastric conditions. Routine peripheral blood information of these patients was collected, and the systemic immune-inflammatory index (SII), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) levels in both groups were calculated and compared. In-depth analysis confirmed that NLR, PLR, and SII exhibited abnormally increased levels in GC and, therefore, had diagnostic significance for distinguishing patients with precancerous gastric conditions from those with GC. Additionally, multivariate logistic regression analysis confirmed that gender and body mass index were risk factors for the occurrence of GC. The findings can provide convenient, low-cost, and highly efficient biological indicators for screening for early GC, as well as more clinical evidence and references for the prevention and management of early GC.