Wu HM, Ying XX, Lv LL, Hu JW. Diagnostic implications of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and systemic immune-inflammatory index for gastric carcinoma. World J Gastrointest Surg 2025; 17(1): 100130 [PMID: 39872777 DOI: 10.4240/wjgs.v17.i1.100130]
Corresponding Author of This Article
Huang-Min Wu, MM, Attending Doctor, Department of Gastroenterology, Dongyang People's Hospital, No. 60 Wuning West Road, Dongyang 322100, Zhejiang Province, China. wuhuanming521@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Surg. Jan 27, 2025; 17(1): 100130 Published online Jan 27, 2025. doi: 10.4240/wjgs.v17.i1.100130
Diagnostic implications of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and systemic immune-inflammatory index for gastric carcinoma
Huang-Min Wu, Xiao-Xuan Ying, Li-Li Lv, Jian-Wen Hu
Huang-Min Wu, Xiao-Xuan Ying, Li-Li Lv, Jian-Wen Hu, Department of Gastroenterology, Dongyang People's Hospital, Dongyang 322100, Zhejiang Province, China
Author contributions: Wu HM contributed to the manuscript writing, data collection and analysis; Wu HM and Ying XX collected data; Wu HM, Lv LL and Hu JW were involved in the conceptualization and supervision of this manuscript; all authors approved the final manuscript.
Institutional review board statement: This study was approved by the Ethic Committee of Dongyang People's Hospital.
Informed consent statement: The requirement for written informed consent was waived due to retrospective design of the study.
Conflict-of-interest statement: Dr. Wu has nothing to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Huang-Min Wu, MM, Attending Doctor, Department of Gastroenterology, Dongyang People's Hospital, No. 60 Wuning West Road, Dongyang 322100, Zhejiang Province, China. wuhuanming521@163.com
Received: August 20, 2024 Revised: September 19, 2024 Accepted: September 27, 2024 Published online: January 27, 2025 Processing time: 129 Days and 4.4 Hours
Core Tip
Core Tip: This study included 133 patients with gastric carcinoma (GC) and 134 with precancerous gastric conditions. Routine peripheral blood information of these patients was collected, and the systemic immune-inflammatory index (SII), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) levels in both groups were calculated and compared. In-depth analysis confirmed that NLR, PLR, and SII exhibited abnormally increased levels in GC and, therefore, had diagnostic significance for distinguishing patients with precancerous gastric conditions from those with GC. Additionally, multivariate logistic regression analysis confirmed that gender and body mass index were risk factors for the occurrence of GC. The findings can provide convenient, low-cost, and highly efficient biological indicators for screening for early GC, as well as more clinical evidence and references for the prevention and management of early GC.
