Actuality and underlying mechanisms of systemic immune-inflammation index and geriatric nutritional risk index prognostic value in hepatocellular carcinoma

Table 1 Impact of neutrophils and platelets on tumor cells

Blood cell	Impact
Neutrophils	Release cytokines, chemokines, and enzymes, degrade extracellular matrix, reduce cell adhesion, and create conditions for tumor cell invasion; promote the adhesion of tumor cells to endothelial cells through physical anchoring that results to the migration of tumor cells[18,19]
Platelets	Pro-angiogenic factors from platelets enhance tumor angiogenesis to meet tumor cells’ supply needs; could form a protective film on the surface of tumor cell that allows: (1) Avoid blood flow damage as well as immune system attack; and (2) Induce the epithelial-mesenchymal transformation of tumor cells that is critical for invasiveness[19,20]