Meta-Analysis
Copyright ©The Author(s) 2022.
World J Gastrointest Surg. Sep 27, 2022; 14(9): 1060-1071
Published online Sep 27, 2022. doi: 10.4240/wjgs.v14.i9.1060
Table 1 Alvarado and appendicitis inflammatory response score

Alvarado score
AIR score
Likely appendicitis7-109-12
Probably appendicitis5-65-8
Unlikely appendicitis0-40-4
Table 2 Groups and categories of severity of Bologna patients

EL (n = 821)
ES (n = 175)
P values
Age (yr)35 (14-94) ± 1836 (14-91) ± 170.50
Male:Female425:396111:64< 0.05
BMI23.85 (14-44) ± 4.424 (17-42) ± 4.50.68
CV comorbidities7.6%24%< 0.05
Other comorbidities13.9%31.4%< 0.05
Edematous AA25150.18
Phlegmonous AA410590.05
Gangrenous AA1601110.05
Table 3 Post-operative complications in Bologna endoloop group

EL (n = 821)
Wound infections2 (0.3%)
Abdominal abscesses12 (1.5%)
Post-op complications IIIa/IIIb Clavien-Dindo17 (2%)
Total post-op complications35 (4.3%)
Table 4 Post-operative complications in Bologna 996 laparoscopic appendectomy patients
Clavien-Dindo
Number of patients (% of total cohort)
I3 (0.3)
II24 (2.4)
IIIa7 (0.7)
IIIb16 (1.6)
IVa0 (0)
IVb0 (0)
V0 (0)
Total50 (5)
Table 5 Complete data to meta-analyse
Ref.
Number of patients (% of EL)
Wound infection
Abdominal abscesses
Post-op complications
Bologna experience821 (78.5)2 (0.3%)12 (1.5%)26 (3.2%)
Ortega et al[9], 1995894 (4.5%)4 (4.5%)14 (15.7%)
Sadat-Safavi et al[19], 201638 (50)1 (2.6%)0 (0%)0 (0%)
Beldi et al[26], 20062565 (39.5)12 (0.5%)41 (1.6%)37 (1.4%)
Sahm et al[29], 20111670 (97.3)34 (2%)27 (1.6%)48 (2.9%)
Van Rossem et al[30], 20171050 (76.7)16 (1.5%)48 (4.5%)20 (1.9%)
Swank et al[31], 2014465 (44.9)7 (1.5%)20 (4.3%)14 (3.1%)
Klima et al[47], 19981003 (3%)4 (4%)4 (4%)
Table 6 Wound infection: Data standard deviation in the meta-analysis
Ref.
Standard deviation
Proportion (%)
95%CI
Our experience8210.2440.0295-0.877
Van Rossem et al[30], 201710501.5240.873-2.463
Sadat-Safavi et al[19], 2016382.6320.0666-13.810
Swank et al[31], 20144651.5050.607-3.077
Sahm et al[29], 201116702.0361.414-2.833
Beldi et al[26], 200625650.4680.242-0.816
Klima et al[47], 19981003.0000.623-8.518
Ortega et al[9], 1995894.4941.238-11.109
Total (fixed effects)67981.0640.834-1.337
Total (random effects)67981.4960.759-2.475
Table 7 Abdominal abscess: Data standard deviation in the meta-analysis
Ref.
Standard deviation
Proportion (%)
95%CI
Our experience8211.4620.757-2.539
Van Rossem et al[30], 201710504.5713.390-6.016
Sadat-Safavi et al[19], 2016380.0000.000-9.251
Swank et al[31], 20144654.3012.647-6.565
Sahm et al[29], 201116701.6171.068-2.344
Beldi et al[26], 200625651.5981.149-2.162
Klima et al[47], 19981004.0001.100-9.926
Ortega et al[9], 1995894.4941.238-11.109
Total (fixed effects)67982.2061.870-2.583
Total (random effects)67982.6991.697-3.924
Table 8 Post-operative complications: Data standard deviation in the meta-analysis
Ref.
Standard deviation
Proportion (%)
95%CI
Our experience8213.1672.079-4.606
Van Rossem et al[30], 201710501.9051.167-2.926
Sadat-Safavi et al[19], 2016380.0000.000-9.251
Swank et al[31], 20144653.0111.656-5.000
Sahm et al[29], 201116702.8742.127-3.793
Beldi et al[26], 200625651.4421.018-1.983
Klima et al[47], 19981004.0001.100-9.926
Ortega et al[9], 19958915.7308.875-24.982
Total (fixed effects)67982.3041.961-2.689
Total (random effects)67983.0891.979-4.437