Utility of preoperative systemic inflammatory biomarkers in predicting postoperative complications after pancreaticoduodenectomy: Literature review and single center experience

Table 1 Demographic characteristics of the study population median value and postsurgical infections characteristics

Demographic characteristics (n = 238) and postoperative complications
Age	68 (59-74)
Median (IQR)
Sex, n (%)
Male	141 (59.2)
Female	97 (40.8)
BMI
Median (kg/m2)	24.9 (22.2-27.7)
Postoperative complications, n (%)
Overall complications	191 (80.2)
Pancreatic fistula	121(50.8)
Pancreatic fistula Grade A	73 (30.6)
Pancreatic fistula Grade B-C	48 (20)
Hemorrhage	34 (14.2)
DGE	73 (30.6)
Abdominal collection	94 (39.5)
Biliary fistula	35 (14.7)
Sepsis	21 (8.8)
Infection of wound	23 (9.6)

BMI: Body mass index; DGE: Delayed gastric emptying; IQR: Interquartile range, 25^th percentile to 75^th percentile.

Table 2 Median levels of pre-operative inflammatory biomarkers

Preoperative inflammatory biomarkers	Median value
NLR (IQR)	227 (164-306)
dNLR (IQR)	1635 (117-21)
CRP (IQR)	53 mg/L (25-1633)

CRP: C-reactive protein; dNLR: Derived neutrophil-to-lymphocyte ratio; IQR: Interquartile range, 25^th percentile to 75^th percentile; NLR: Neutrophil-to-lymphocyte ratio.

Table 3 Statistical significance of preoperative inflammatory biomarkers

	Overall complications	Abdominal collection	PPH
NLR > 1.65	Ns	Ns	P = 0.016
dNLR > 1.47	Ns	P = 0.021
CRP > 881 mg/L	P = 0.0037	P = 0.016	Ns

CRP: C-reactive protein; dNLR: Derived neutrophil-to-lymphocyte ratio; NLR: Neutrophil-to-lymphocyte ratio; Ns: Not significant; PPH: Postoperative hemorrhage.