Coppola A, La Vaccara V, Caggiati L, Carbone L, Spoto S, Ciccozzi M, Angeletti S, Coppola R, Caputo D. Utility of preoperative systemic inflammatory biomarkers in predicting postoperative complications after pancreaticoduodenectomy: Literature review and single center experience. World J Gastrointest Surg 2021; 13(10): 1216-1225 [PMID: 34754389 DOI: 10.4240/wjgs.v13.i10.1216]
Corresponding Author of This Article
Damiano Caputo, FACS, MD, Associate Professor, Surgeon, Department of General Surgery, University Campus Bio-Medico di Roma, Via Alvaro del Portillo, 200, Rome 00128, Italy. d.caputo@unicampus.it
Research Domain of This Article
Surgery
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Surg. Oct 27, 2021; 13(10): 1216-1225 Published online Oct 27, 2021. doi: 10.4240/wjgs.v13.i10.1216
Utility of preoperative systemic inflammatory biomarkers in predicting postoperative complications after pancreaticoduodenectomy: Literature review and single center experience
Alessandro Coppola, Vincenzo La Vaccara, Lorenza Caggiati, Ludovico Carbone, Silvia Spoto, Massimo Ciccozzi, Silvia Angeletti, Roberto Coppola, Damiano Caputo
Alessandro Coppola, Department of Surgery, University Campus Bio-Medico di Roma, Rome 00128, Italy
Vincenzo La Vaccara, Lorenza Caggiati, Ludovico Carbone, Roberto Coppola, Damiano Caputo, Department of General Surgery, University Campus Bio-Medico di Roma, Rome 00128, Italy
Silvia Spoto, Department of Internal Medicine, University Campus Bio-Medico di Roma, Rome 00128, Italy
Massimo Ciccozzi, Medical Statistics and Epidemiology Unit, University Campus Bio-Medico di Roma, Rome 00128, Italy
Silvia Angeletti, Unit of Clinical Laboratory Science, University Campus Bio-Medico di Roma, Rome 00128, Italy
Author contributions: Caputo D and Coppola A designed the research study; Caggiati L and Ludovico C collected the data; Caputo D, Ciccozzi M, Angeletti S and Spoto S analyzed and interpreted data; Caputo D, Coppola A and Caggiati L drafted the article; Caputo D, Spoto S, Angeletti S and Coppola R made critical revision of the article; All the authors gave the final approval of the version to be published.
Institutional review board statement: The local Ethical Committee approved the study (28/19 OSS ComEt CBM).
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: All authors declare that they do not have any conflict of interest.
Data sharing statement: Dataset will be available from the corresponding author at d.caputo@unicampus.it according to local laws.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Damiano Caputo, FACS, MD, Associate Professor, Surgeon, Department of General Surgery, University Campus Bio-Medico di Roma, Via Alvaro del Portillo, 200, Rome 00128, Italy. d.caputo@unicampus.it
Received: January 25, 2021 Peer-review started: January 25, 2021 First decision: May 3, 2021 Revised: May 10, 2021 Accepted: July 13, 2021 Article in press: July 13, 2021 Published online: October 27, 2021 Processing time: 273 Days and 21 Hours
ARTICLE HIGHLIGHTS
Research background
Role of preoperative inflammatory biomarkers (PIBs) in predicting postoperative morbidity has been widely assessed in colorectal and otorhinolaryngeal surgery.
Research motivation
To date, little is known about the role of PIBs in predicting pancreaticoduodenectomy (PD) postoperative complications.
Research objectives
To exploit the utility of PIBs in predicting the postoperative course after PD.
Research methods
A literature research and a retrospective analysis of data from a prospective collected database of 317 consecutive pancreaticoduodenectomies have been performed. Data regarding preoperative neutrophil-to-lymphocyte ratio (NLR), derived NLR (dNLR), platelet-lymphocyte ratio, C-reactive protein (CRP) and postoperative complications of 238 cases have been analyzed. PIBs were compared using MannWhitney’s test and receiver operating characteristic (ROC) analysis was performed to define the cutoffs.
Research results
Patients with preoperative CRP > 8.81 mg/dL were at higher risk of both overall complications and abdominal collections (respectively P = 0.0037, PPV = 0.95, NPV = 0.27 and P = 0.016, PPV = 0.59, NPV = 0.68). _Preoperative dNLR (cut off > 1.47) was also predictor of abdominal collection (P = 0.021, PPV = 0.48, NPV = 0.71). Combining CRP and dNLR, PPV increased to 0.67. NLR (cut off > 1.65) was significantly associated with postoperative hemorrhage (P = 0.016, PPV = 0.17, NPV = 0.98).
Research conclusions
PIBS are cost-effective tools that may predict complications after pancreaticoduodenectomy and could be useful in the postoperative management.
Research perspectives
In clinical practice, PIBs could be used during the postoperative course of PD decisions regarding timing of drains removal and selection of patients who can benefit from second level diagnostic exams (e.g., CT scan).
