Letter to the Editor
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Dec 27, 2024; 16(12): 3881-3886
Published online Dec 27, 2024. doi: 10.4240/wjgs.v16.i12.3881
Therapeutic efficacy of immunotherapy for gastric cancer metastasis
Fei-Fei Xie, Su-Ting Qian, Hao-Yu Zhao, Qing-Sheng Liu
Fei-Fei Xie, Su-Ting Qian, Hao-Yu Zhao, Department of Digestive, Hangzhou Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University, Hangzhou 310007, Zhejiang Province, China
Qing-Sheng Liu, Science and Education Section, Hangzhou Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University, Hangzhou 310007, Zhejiang Province, China
Author contributions: Xie FF, Qian ST, Zhao HY and Liu QS contributed to this paper; Liu QS designed the overall concept and outline of the manuscript; Xie FF and Qian ST contributed to the design and writing of the manuscript; Xie FF and Zhao HY contributed to the editing the manuscript, illustrations, and review of literature.
Supported by Traditional Chinese Medicine Science and Technology Program of Zhejiang Province and Key Medical and Health Program of Hangzhou City from Zhejiang Province Administration of Traditional Chinese Medicine, No. ZD20210047 and No. 2023ZL091.
Conflict-of-interest statement: All authors have no conflict-of-interest to disclose.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Qing-Sheng Liu, MM, Chief Doctor, Science and Education Section, Hangzhou Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University, No. 453 Stadium Road, Hangzhou 310007, Zhejiang Province, China. 7394822@qq.com
Received: July 18, 2024
Revised: September 24, 2024
Accepted: October 22, 2024
Published online: December 27, 2024
Processing time: 133 Days and 21.6 Hours
Core Tip

Core Tip: Immunotherapy has gradually begun to be applied in the treatment of gastric cancer (GC) metastasis. Some studies have shown that liver metastases of advanced GC have a reduced immune response rate due to the presence of hepatic immune tolerance mechanisms. Therefore, the mechanism and efficacy of immunotherapy applied in other metastases are discussed. Previous studies have shown that immunotherapy has the best efficacy for lung metastasis and the worst efficacy for peritoneal metastasis, but it has a good safety profile and is promising for use in all GC metastases.