Basic Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Dec 27, 2024; 16(12): 3843-3856
Published online Dec 27, 2024. doi: 10.4240/wjgs.v16.i12.3843
Zinc pretreatment for protection against intestinal ischemia-reperfusion injury
Ming-Zhen Cheng, Jia-Hao Luo, Xin Li, Feng-Yong Liu, Wei-Jie Zhou
Ming-Zhen Cheng, Jia-Hao Luo, Wei-Jie Zhou, State Key Laboratory of Organ Failure Research, Department of General Surgery, Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China
Xin Li, Department of Interventional Radiology, The Fifth Medical Centre, Chinese PLA General Hospital, Beijing 100071, China
Feng-Yong Liu, Department of Interventional Radiology, Senior Department of Oncology, The Fifth Medical Centre, Chinese PLA General Hospital, Beijing 100071, China
Co-first authors: Ming-Zhen Cheng and Jia-Hao Luo.
Co-corresponding authors: Feng-Yong Liu and Wei-Jie Zhou.
Author contributions: Cheng MZ and Luo JH contribute equally to this study as co-first authors. Liu FY and Zhou WJ contribute equally to this study as co-corresponding authors. Zhou WJ and Liu FY conceptualized the study; Cheng MZ, Luo JH and LX performed the experiments, the formal analysis, and the validation investigations; Cheng MZ collected the data; Zhou WJ and Liu FY wrote the original drafts; Zhou WJ wrote, reviewed and edited the manuscript; all authors have read and approved the final manuscript.
Institutional animal care and use committee statement: Animal-related research protocols were consistent with the United States Public Health Service Policy on the Use of Laboratory Animals and were approved by the Ethics Committee on the Use and Care of Animals of Southern Medical University.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The data and materials used in this study are available from Zhou WJ (weijiezhouum@163.com) upon reasonable request.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wei-Jie Zhou, PhD, Professor, State Key Laboratory of Organ Failure Research, Department of General Surgery, Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, Southern Medical University, No. 1838 Guangzhou Road, Guangzhou 510515, Guangdong Province, China. weijiezhouum@163.com
Received: August 26, 2024
Revised: October 1, 2024
Accepted: October 28, 2024
Published online: December 27, 2024
Processing time: 92 Days and 23.2 Hours
Core Tip

Core Tip: This study demonstrated the protective effects of zinc pretreatment on reducing oxidative stress, apoptosis, and multiorgan damage during intestinal ischemia-reperfusion injury (II/RI). Using mouse models and in vitro systems, zinc significantly mitigated damage in the intestine, liver, and kidneys by reducing reactive oxygen species production and enhancing cellular resilience to hypoxic injury. These findings highlight the potential clinical applications of zinc in protecting against II/RI and improving outcomes in patients experiencing ischemic events.