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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Dec 27, 2023; 15(12): 2757-2764
Published online Dec 27, 2023. doi: 10.4240/wjgs.v15.i12.2757
Published online Dec 27, 2023. doi: 10.4240/wjgs.v15.i12.2757
Efficacy of pantoprazole plus perforation repair for peptic ulcer and its effect on the stress response
Zi-Yan Leng, The Second Hospital of Traditional Chinese Medicine of Jiangsu Province, Affiliated to Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu Province, China
Jia-Hao Wang, Institute of Literature in Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu Province, China
Lei Gao, School of Chinese Medicine & School of Integrated, Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu Province, China
Ke Shi, Hai-Bing Hua, Department of Spleen and Gastroenterology, Jiangyin Hospital Affiliated to Nanjing University of Chinese Medicine, Jiangyin 214400, Jiangsu Province, China
Author contributions: Leng ZY and Hua HB designed the research and wrote the first manuscript; Leng ZY, Wang JH, Gao L, Shi K and Hua HB contributed to conceiving the research and analyzing data; Leng ZY and Hua HB conducted the analysis and provided guidance for the research; all authors reviewed and approved the final manuscript.
Institutional review board statement: This study was approved by the Ethic Committee of Jiangyin Hospital Affiliated to Nanjing University of Chinese Medicine.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: Dr. Hua has nothing to disclose.
Data sharing statement: All data and materials are available from the corresponding author.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hai-Bing Hua, Doctor, Chief Physician, Department of Spleen and Gastroenterology, Jiangyin Hospital Affiliated to Nanjing University of Chinese Medicine, No. 130 Renmin Middle Road, Jiangyin 214400, Jiangsu Province, China. jyhhb75@163.com
Received: September 14, 2023
Peer-review started: September 14, 2023
First decision: October 8, 2023
Revised: October 23, 2023
Accepted: November 25, 2023
Article in press: November 25, 2023
Published online: December 27, 2023
Peer-review started: September 14, 2023
First decision: October 8, 2023
Revised: October 23, 2023
Accepted: November 25, 2023
Article in press: November 25, 2023
Published online: December 27, 2023
Core Tip
Core Tip: Peptic ulcer (PU), as a chronic disease, may cause complications such as perforation, upper gastrointestinal bleeding, and rarely gastric outlet obstruction. Risk factors such as advanced age, a history of PU, Helicobacter pylori infection, and the use of nonsteroidal anti-inflammatory drugs further increase the risk of developing the disease. To further reduce the associated negative effects of the disease, this study aims to explore and seek new therapeutic models to improve the management of the disease.