Leng ZY, Wang JH, Gao L, Shi K, Hua HB. Efficacy of pantoprazole plus perforation repair for peptic ulcer and its effect on the stress response. World J Gastrointest Surg 2023; 15(12): 2757-2764 [PMID: 38222001 DOI: 10.4240/wjgs.v15.i12.2757]
Corresponding Author of This Article
Hai-Bing Hua, Doctor, Chief Physician, Department of Spleen and Gastroenterology, Jiangyin Hospital Affiliated to Nanjing University of Chinese Medicine, No. 130 Renmin Middle Road, Jiangyin 214400, Jiangsu Province, China. jyhhb75@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Surg. Dec 27, 2023; 15(12): 2757-2764 Published online Dec 27, 2023. doi: 10.4240/wjgs.v15.i12.2757
Efficacy of pantoprazole plus perforation repair for peptic ulcer and its effect on the stress response
Zi-Yan Leng, Jia-Hao Wang, Lei Gao, Ke Shi, Hai-Bing Hua
Zi-Yan Leng, The Second Hospital of Traditional Chinese Medicine of Jiangsu Province, Affiliated to Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu Province, China
Jia-Hao Wang, Institute of Literature in Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu Province, China
Lei Gao, School of Chinese Medicine & School of Integrated, Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu Province, China
Ke Shi, Hai-Bing Hua, Department of Spleen and Gastroenterology, Jiangyin Hospital Affiliated to Nanjing University of Chinese Medicine, Jiangyin 214400, Jiangsu Province, China
Author contributions: Leng ZY and Hua HB designed the research and wrote the first manuscript; Leng ZY, Wang JH, Gao L, Shi K and Hua HB contributed to conceiving the research and analyzing data; Leng ZY and Hua HB conducted the analysis and provided guidance for the research; all authors reviewed and approved the final manuscript.
Institutional review board statement: This study was approved by the Ethic Committee of Jiangyin Hospital Affiliated to Nanjing University of Chinese Medicine.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: Dr. Hua has nothing to disclose.
Data sharing statement: All data and materials are available from the corresponding author.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hai-Bing Hua, Doctor, Chief Physician, Department of Spleen and Gastroenterology, Jiangyin Hospital Affiliated to Nanjing University of Chinese Medicine, No. 130 Renmin Middle Road, Jiangyin 214400, Jiangsu Province, China. jyhhb75@163.com
Received: September 14, 2023 Peer-review started: September 14, 2023 First decision: October 8, 2023 Revised: October 23, 2023 Accepted: November 25, 2023 Article in press: November 25, 2023 Published online: December 27, 2023
ARTICLE HIGHLIGHTS
Research background
Peptic ulcer (PU) is an abnormal phenomenon of rupture of the mucosa of the digestive tract, which not only affects patients' normal life but also causes an economic burden due to its high medical costs.
Research motivation
There is an urgent need to improve the management of PU from the treatment model and to provide effective treatment options and new clinical references for patients with the disease.
Research objectives
This study investigated the efficacy of pantoprazole (PPZ) plus perforation repair in patients with PU and its effect on the stress response.
Research methods
The study subjects were 108 PU patients admitted between July 2018 and July 2022, including 58 patients receiving PPZ plus perforation repair [research group (RG)] and 50 patients given simple perforation repair [control group (CG)]. The efficacy, somatostatin (SS) concentration, stress reaction [malondialdehyde (MDA), lipid peroxide (LPO)], inflammatory indices [tumor necrosis factor (TNF)-α, C-reactive protein (CRP), interleukin (IL)-1β], recurrence, and complications (perforation, hemorrhage, and pyloric obstruction) were compared.
Research results
The overall response rate was higher in RG than in CG. RG had markedly elevated SS after treatment, which was higher than that of CG, while MDA, LPO, TNF-α, CRP, and IL-1β were significantly reduced to lower than those in CG. Lower recurrence and complication rates were identified in RG.
Research conclusions
Therefore, PPZ plus perforation repair is conducive to enhancing treatment outcomes in PU patients, reducing oxidative stress injury and excessive inflammatory reactions, and contributing to low recurrence and complication rates.
Research perspectives
PPZ plus perforation repair is effective in the treatment of PU patients, which can inhibit stress response by down-regulating MDA and LPO and up-regulating SS, alleviate inflammation by down-regulating TNF-α, CRP and IL-1β levels, and help reduce the risk of recurrence and complications. Our paper develops a theoretical foundation for the prevention and treatment of PU patients and provides a new treatment option and direction for the management of the disease.
