Retrospective Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Oct 27, 2023; 15(10): 2247-2258
Published online Oct 27, 2023. doi: 10.4240/wjgs.v15.i10.2247
Novel prognostic score based on the preoperative total bilirubin-albumin ratio and fibrinogen-albumin ratio in ampullary adenocarcinoma
Xiao-Jie Zhang, He Fei, Chong-Yuan Sun, Ze-Feng Li, Zheng Li, Chun-Guang Guo, Dong-Bing Zhao
Xiao-Jie Zhang, He Fei, Chong-Yuan Sun, Ze-Feng Li, Zheng Li, Chun-Guang Guo, Dong-Bing Zhao, Department of Pancreatic and Gastric Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
Author contributions: Zhang XJ and Fei H contributed equally to this work; Guo CG and Zhao DB designed the research study, they are the corresponding authors of this paper; Fei H and Zhang XJ analyzed the data; all authors wrote the manuscript; and all authors have read and approved the final manuscript.
Institutional review board statement: Ethical review and approval were not required for the study on human participants in accordance with the National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College.
Informed consent statement: Ethical review and approval were not required for the study on human participants in accordance with the local legislation and institutional requirements.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Dong-Bing Zhao, MD, Doctor, Department of Pancreatic and Gastric Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17 Panjiayuan Nanli, Chaoyang District, Beijing 100021, China. dbzhao@cicams.ac.cn
Received: July 3, 2023
Peer-review started: July 3, 2023
First decision: August 17, 2023
Revised: August 22, 2023
Accepted: September 4, 2023
Article in press: September 4, 2023
Published online: October 27, 2023
Processing time: 115 Days and 19 Hours
Core Tip

Core Tip: Considering that effective prognostic predictors are still lacking for ampullary carcinoma, we conducted a retrospective study to elucidate the prognostic value of total bilirubin-albumin ratio (TBAR) and fibrinogen-albumin ratio (FAR) in ampullary adenocarcinoma (AC) patients who underwent curative pancreaticoduodenectomy. We found that the novel prognostic score based on the preoperative TBAR and FAR was an independent predictor for tumor recurrence and an independent protective factor for overall survival in AC patients who underwent curative pancreaticoduodenectomy.