Retrospective Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Oct 27, 2023; 15(10): 2247-2258
Published online Oct 27, 2023. doi: 10.4240/wjgs.v15.i10.2247
Novel prognostic score based on the preoperative total bilirubin-albumin ratio and fibrinogen-albumin ratio in ampullary adenocarcinoma
Xiao-Jie Zhang, He Fei, Chong-Yuan Sun, Ze-Feng Li, Zheng Li, Chun-Guang Guo, Dong-Bing Zhao
Xiao-Jie Zhang, He Fei, Chong-Yuan Sun, Ze-Feng Li, Zheng Li, Chun-Guang Guo, Dong-Bing Zhao, Department of Pancreatic and Gastric Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
Author contributions: Zhang XJ and Fei H contributed equally to this work; Guo CG and Zhao DB designed the research study, they are the corresponding authors of this paper; Fei H and Zhang XJ analyzed the data; all authors wrote the manuscript; and all authors have read and approved the final manuscript.
Institutional review board statement: Ethical review and approval were not required for the study on human participants in accordance with the National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College.
Informed consent statement: Ethical review and approval were not required for the study on human participants in accordance with the local legislation and institutional requirements.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Dong-Bing Zhao, MD, Doctor, Department of Pancreatic and Gastric Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17 Panjiayuan Nanli, Chaoyang District, Beijing 100021, China. dbzhao@cicams.ac.cn
Received: July 3, 2023
Peer-review started: July 3, 2023
First decision: August 17, 2023
Revised: August 22, 2023
Accepted: September 4, 2023
Article in press: September 4, 2023
Published online: October 27, 2023
Processing time: 115 Days and 19 Hours
ARTICLE HIGHLIGHTS
Research background

Whether the relationship of preoperative total bilirubin, fibrinogen, and albumin could be used as prognostic factors is still debated.

Research motivation

The present study attempted to explore the prognostic value of total bilirubin-albumin ratio (TBAR) and fibrinogen-albumin ratio (FAR) in ampullary adenocarcinoma (AC) patients who underwent curative pancreaticoduodenectomy.

Research objectives

This study aimed to investigate whether there was an association between the novel prognostic score and poor oncologic outcomes in ampullary carcinoma.

Research methods

The clinicopathological data of ampullary carcinoma patients who underwent surgery from January 1998 to January 2020 were analyzed. Then, a novel prognostic score combining TBAR and FAR was calculated and validated through logistic regression analysis and Cox regression analysis.

Research results

Multivariable logistic regression analysis revealed that a high score was an independent protective factor for recurrence. In addition, multivariable survival analysis also demonstrated that a high score was an independent protective factor in AC patients.

Research conclusions

We found that the novel prognostic score based on the preoperative TBAR and FAR has good predictive power in AC patients who underwent curative pancreaticoduodenectomy.

Research perspectives

There are several limitations in this retrospective study, and more studies with larger samples are needed to validate this conclusion.